Differentiation of Native and Reconstructed Ferritin using the MRI Gradient Echo Pulse Sequence

• Authors: L. Balejcikova , O. Strbak , L. Baciak , J. Kovac , M. Masarova , A. Krafcik , P. Kopcansky , D. Dobrota , I. Frollo
• Languages of publication: EN

Abstracts

EN

Ferritin is a biological iron storage biomacromolecule, consisting of a spherical protein shell (apoferritin) and mineral iron core. It plays a crucial role in the pathological processes of disrupted iron homeostasis followed by iron accumulation, linked with various disorders (e.g. neuroinflammation, neurodegeneration, cirrhosis, cancer, etc.) In vitro reconstructed ferritin, with the assistance of a non-invasive magnetic resonance imaging technique, has the potential to become a suitable biomarker of these pathological processes. Through gradient echo pulse sequencing, we were able to clearly distinguish between native (physiological) and reconstructed/iron-overloaded (pathological) ferritin, which can serve as a starting point for the development of a method for their differentiation. Such method is necessary for the early diagnosis of iron-based diseases.

Keywords

EN

75.60.Ej; 83.85.Fg; 87.61.-c; 87.64.Cc; 87.85.jf

Discipline

• 83.85.Fg: NMR/magnetic resonance imaging(see also 76.60.Pc NMR imaging in condensed matter)
• 87.61.-c: Magnetic resonance imaging
• 87.64.Cc: Scattering of visible, uv, and infrared radiation
• 75.60.Ej: Magnetization curves, hysteresis, Barkhausen and related effects(for hysteresis in ferroelectricity, see 77.80.Dj)
• 87.85.jf: Bio-based materials

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2017
• Volume: 131
• Issue: 4
• Pages: 1093-1095

Dates

published

2017-04

Contributors

author

L. Balejcikova

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
• Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia

author

O. Strbak

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
• Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia

author

L. Baciak

• Faculty of Chemical and Food Technology STU, Radlinskeho 9, 812 37 Bratislava, Slovakia

author

J. Kovac

• Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia

author

M. Masarova

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia

author

A. Krafcik

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia

author

P. Kopcansky

• Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia

author

D. Dobrota

• Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia

author

I. Frollo

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia

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Identifiers

DOI

10.12693/APhysPolA.131.1093