Journal
Article title
Authors
Title variants
Languages of publication
Abstracts
Ferritin is a biological iron storage biomacromolecule, consisting of a spherical protein shell (apoferritin) and mineral iron core. It plays a crucial role in the pathological processes of disrupted iron homeostasis followed by iron accumulation, linked with various disorders (e.g. neuroinflammation, neurodegeneration, cirrhosis, cancer, etc.) In vitro reconstructed ferritin, with the assistance of a non-invasive magnetic resonance imaging technique, has the potential to become a suitable biomarker of these pathological processes. Through gradient echo pulse sequencing, we were able to clearly distinguish between native (physiological) and reconstructed/iron-overloaded (pathological) ferritin, which can serve as a starting point for the development of a method for their differentiation. Such method is necessary for the early diagnosis of iron-based diseases.
Discipline
- 83.85.Fg: NMR/magnetic resonance imaging(see also 76.60.Pc NMR imaging in condensed matter)
- 87.61.-c: Magnetic resonance imaging
- 87.64.Cc: Scattering of visible, uv, and infrared radiation
- 75.60.Ej: Magnetization curves, hysteresis, Barkhausen and related effects(for hysteresis in ferroelectricity, see 77.80.Dj)
- 87.85.jf: Bio-based materials
Journal
Year
Volume
Issue
Pages
1093-1095
Physical description
Dates
published
2017-04
Contributors
author
- Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
- Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia
author
- Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
- Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia
author
- Faculty of Chemical and Food Technology STU, Radlinskeho 9, 812 37 Bratislava, Slovakia
author
- Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia
author
- Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
author
- Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
author
- Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia
author
- Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia
author
- Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
References
- [1] C.W. Connie, M.D. Hsia, N. Engl. J. Med. 338, 239 (1998), doi: 10.1056/NEJM199801223380407
- [2] D. Finazzi, P. Arosio, Arch. Toxicol. 88, 1787 (2014), doi: 10.1007/s00204-014-1329-0
- [3] N.D. Chasteen, P.M. Harrison, J. Struct. Biol. 126, 182 (1999), doi: 10.1006/jsbi.1999.4118
- [4] E.C. Theil, H. Takagi, G.W. Small, L. He, A.R. Tipton, D. Danger, Inorg. Chim. Acta 297, 242 (2000), doi: 10.1016/S0020-1693(99)00375-8
- [5] M. Wagstaff, M. Worwood, A. Jacobs, Biochem. J. 173, 969 (1978), doi: 10.1042/bj1730969
- [6] Y. Ren, T. Walczyk, Metallomics 6, 1709 (2014), doi: 10.1039/C4MT00127C
- [7] Y.-H. Pan, K. Sader, J.J. Powell, A. Bleloch, M. Gass, J. Trinick, A. Warley, A. Li, R. Brydson, A. Brown, J. Struct. Biol. 166, 22 (2009), doi: 10.1016/j.jsb.2008.12.001
- [8] A. Friedman, P. Arosio, D. Finazzi, D. Koziorowski, J. Galazka-Friedman, Parkinsonism Relat. Disord. 17, 423 (2011), doi: 10.1016/j.parkreldis.2011.03.016
- [9] M.J. Williams, R. Poulton, S. Williams, Atherosclerosis 165, 179 (2002), doi: 10.1016/S0021-9150(02)00233-2
- [10] A.A. Alkhateeb, J.R. Connor, Biochim. Biophys. Acta 1836, 245 (2013), doi: 10.1016/j.bbcan.2013.07.002
- [11] P. Nielsen, U. Günther, M. Dürken, R. Fischer, J. Düllmann, J. Lab. Clin. Med. 135, 413 (2000), doi: 10.1067/mlc.2000.106456
- [12] Z. Mitróová, L. Melníková, J. Kováč, M. Timko, P. Kopčanský, Acta Phys. Pol. A 121, 1318 (2012), doi: 10.12693/APhysPolA.121.1318
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv131n4158kz