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2017 | 131 | 4 | 1093-1095
Article title

Differentiation of Native and Reconstructed Ferritin using the MRI Gradient Echo Pulse Sequence

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EN
Abstracts
EN
Ferritin is a biological iron storage biomacromolecule, consisting of a spherical protein shell (apoferritin) and mineral iron core. It plays a crucial role in the pathological processes of disrupted iron homeostasis followed by iron accumulation, linked with various disorders (e.g. neuroinflammation, neurodegeneration, cirrhosis, cancer, etc.) In vitro reconstructed ferritin, with the assistance of a non-invasive magnetic resonance imaging technique, has the potential to become a suitable biomarker of these pathological processes. Through gradient echo pulse sequencing, we were able to clearly distinguish between native (physiological) and reconstructed/iron-overloaded (pathological) ferritin, which can serve as a starting point for the development of a method for their differentiation. Such method is necessary for the early diagnosis of iron-based diseases.
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Contributors
  • Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
  • Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia
author
  • Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
  • Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia
author
  • Faculty of Chemical and Food Technology STU, Radlinskeho 9, 812 37 Bratislava, Slovakia
author
  • Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia
author
  • Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
author
  • Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
author
  • Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia
author
  • Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia
author
  • Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv131n4158kz
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