Stability of Ferrous Fumarate in Medicaments for Women: Application of Mössbauer Spectroscopy

• Authors: M. Kądziołka-Gaweł , M. Wojtyniak
• Languages of publication: EN

Abstracts

EN

Determination of the iron state (Fe²⁺ or Fe³⁺) and content of iron in commercial pharmaceutical products containing ferrous fumarate FeC₄H₂O₄ was made by the Mössbauer spectroscopy and X-ray fluorescence method. Also, influence of thermal treatment on stability of ferrous fumarate in selected medicaments has been investigated. The investigated samples were annealed in definite temperature: 373, 473, and 573 K for 5 h. Room temperature Mössbauer spectra of initial samples gave clear evidence that two phases of iron were presented. The major component was connected with ferrous fumarate with a contribution from ≈85% to ≈50%, depending on investigated medicaments. Ferrous fumarate was stable up to annealing temperature 473 K. Above this temperature significant oxidation of Fe²⁺ to Fe³⁺ was observed.

Keywords

EN

87.64.kx

Discipline

• 87.64.kx: Mössbauer

• Journal: Acta Physica Polonica A
• Year: 2016
• Volume: 129
• Issue: 6
• Pages: 1242-1244

Dates

published

2016-06

received

2015-10-05

(unknown)

2016-03-22

Contributors

author

M. Kądziołka-Gaweł

• Institute of Physics, Silesian University, Uniwersytecka 4, 40-700 Katowice, Poland

author

M. Wojtyniak

• Institute of Physics, Silesian University, Uniwersytecka 4, 40-700 Katowice, Poland

References

• [1] N.D. Chasteen, P.M. Harrison, J. Struct. Biol. 126, 189 (1999), doi: 10.1006/jsbi.1999.4118
• [2] A.J. Kapor, L.B. Nikolić, V.D. Nikolić, Adv. Technol. 1, 07 (2012)
• [3] M.I. Oshtrakh, O.B. Milder, V.A. Semionkin, Hyp. Interact. 156/157, 273 (2004), doi: 10.1023/B:HYPE.0000043240.66860.5e
• [4] B.F. Matzanke, D.J. Ecker, T.S. Yang, B.H. Huynh, G. Muller, K.M. Raymond, J. Bacteriol. 167, 674 (1986)
• [5] M.I. Oshtrakh, O.B. Milder, V.A. Semionkin, J. Radioanal. Nucl. Chem. 269, 547 (2006), doi: 10.1016/j.jpba.2005.09.020
• [6] M. Kądziołka-Gaweł, M. Michałowska, Acta Phys. Pol. A 127, 653 (2014), doi: 10.12693/APhysPolA.127.653
• [7] E.M. Coe, L.H. Bowen, R.D. Bereman, J. Inorg. Biochem. 58, 291 (1995), doi: 10.1016/0162-0134(94)00062-F
• [8] R. Gozdyra, S.M. Dubiel, J. Cieślak, J. Phys. 217, 012146 (2010), doi: 10.1088/1742-6596/217/1/012146
• [9] V. Nikolić, M. Stanković, A. Kapor, Lj. Nikolić, D. Cvetković, J. Stamenković, Pharmazie 59, 845 (2004)
• [10] A. Kapor, V. Nikolić, Lj. Nikolić, M. Stanković, M. Cakić, Lj. Stanojević, Cent. Eur. J. Chem. 8, 843 (2010), doi: 10.2478/s11532-010-0061-8
• [11] G.F. Goya, S.J. Stewart, R.C. Mercader, Solid State Commun. 96, 485 (1995), doi: 10.1016/0038-1098(95)00451-3

Identifiers

DOI

10.12693/APhysPolA.129.1242