Stability of Ferrous Fumarate in Medicaments for Women: Application of Mössbauer Spectroscopy

• Authors: M. Kądziołka-Gaweł , M. Wojtyniak
• Languages of publication: EN

Abstracts

EN

Determination of the iron state (Fe²⁺ or Fe³⁺) and content of iron in commercial pharmaceutical products containing ferrous fumarate FeC₄H₂O₄ was made by the Mössbauer spectroscopy and X-ray fluorescence method. Also, influence of thermal treatment on stability of ferrous fumarate in selected medicaments has been investigated. The investigated samples were annealed in definite temperature: 373, 473, and 573 K for 5 h. Room temperature Mössbauer spectra of initial samples gave clear evidence that two phases of iron were presented. The major component was connected with ferrous fumarate with a contribution from ≈85% to ≈50%, depending on investigated medicaments. Ferrous fumarate was stable up to annealing temperature 473 K. Above this temperature significant oxidation of Fe²⁺ to Fe³⁺ was observed.

Keywords

EN

87.64.kx

Discipline

• 87.64.kx: Mössbauer

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2016
• Volume: 129
• Issue: 6
• Pages: 1242-1244

Dates

published

2016-06

received

2015-10-05

(unknown)

2016-03-22

Contributors

author

M. Kądziołka-Gaweł

• Institute of Physics, Silesian University, Uniwersytecka 4, 40-700 Katowice, Poland

author

M. Wojtyniak

• Institute of Physics, Silesian University, Uniwersytecka 4, 40-700 Katowice, Poland

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Identifiers

DOI

10.12693/APhysPolA.129.1242