Effect of Magnetite Composite on the Amount of Double Strand Breaks Induced with X-Rays

• Authors: A. Wiecheć , K. Nowicka , M. Błażewicz , W. Kwiatek
• Languages of publication: EN

Abstracts

EN

The aim of this study was to find out if polylactide (PLA) modified with magnetite might affect the amount of DNA double strand breaks induced with X-rays. The human osteosarcoma cells (MG63) were seeded on the polystyrene cell culture dishes (PS), PLA and PLA modified with magnetite substrates. The double strand breaks were analyzed after X-ray irradiation (dose rate 2 Gy/min), in the first day of culturing. The number of double strand breaks increased in the PLA modified with magnetite, for example after 1 Gy of X-rays irradiation, double strand breaks/cell equaled: 24.5 vs. 17.5 and 17.3, for PLA modified with magnetite vs. PLA and PS, p < 0.0003. We conclude that PLA modified with magnetite changed the number of double strand breaks induced with X-rays. However, more research is needed to confirm that such composite might be considered as radiosensitizer in radiotherapy.

Keywords

EN

87.50.-a; 87.53.-j; 81.05.Mh; 81.05.Ni; 81.05.Pj; 81.05.Qk; 75.50.Bb

Discipline

• 81.05.Ni: Dispersion-, fiber-, and platelet-reinforced metal-based composites
• 87.53.-j: Effects of ionizing radiation on biological systems
• 81.05.Mh: Cermets, ceramic and refractory composites
• 81.05.Qk: Reinforced polymers and polymer-based composites
• 87.50.-a: Effects of electromagnetic and acoustic fields on biological systems
• 75.50.Bb: Fe and its alloys
• 81.05.Pj: Glass-based composites, vitroceramics

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2016
• Volume: 129
• Issue: 2
• Pages: 174-175

Dates

published

2016-02

Contributors

author

A. Wiecheć

• Institute of Nuclear Physics, Polish Academy of Sciences, PL-31342 Kraków, Poland

author

K. Nowicka

• AGH University of Science and Technology, Faculty of Material Science and Ceramic, Department of Biomaterials, Kraków, Poland

author

M. Błażewicz

• AGH University of Science and Technology, Faculty of Material Science and Ceramic, Department of Biomaterials, Kraków, Poland

author

W. Kwiatek

• Institute of Nuclear Physics, Polish Academy of Sciences, PL-31342 Kraków, Poland

References

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Identifiers

DOI

10.12693/APhysPolA.129.174