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2016 | 129 | 2 | 174-175
Article title

Effect of Magnetite Composite on the Amount of Double Strand Breaks Induced with X-Rays

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EN
Abstracts
EN
The aim of this study was to find out if polylactide (PLA) modified with magnetite might affect the amount of DNA double strand breaks induced with X-rays. The human osteosarcoma cells (MG63) were seeded on the polystyrene cell culture dishes (PS), PLA and PLA modified with magnetite substrates. The double strand breaks were analyzed after X-ray irradiation (dose rate 2 Gy/min), in the first day of culturing. The number of double strand breaks increased in the PLA modified with magnetite, for example after 1 Gy of X-rays irradiation, double strand breaks/cell equaled: 24.5 vs. 17.5 and 17.3, for PLA modified with magnetite vs. PLA and PS, p < 0.0003. We conclude that PLA modified with magnetite changed the number of double strand breaks induced with X-rays. However, more research is needed to confirm that such composite might be considered as radiosensitizer in radiotherapy.
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Contributors
author
  • Institute of Nuclear Physics, Polish Academy of Sciences, PL-31342 Kraków, Poland
author
  • AGH University of Science and Technology, Faculty of Material Science and Ceramic, Department of Biomaterials, Kraków, Poland
  • AGH University of Science and Technology, Faculty of Material Science and Ceramic, Department of Biomaterials, Kraków, Poland
author
  • Institute of Nuclear Physics, Polish Academy of Sciences, PL-31342 Kraków, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv129n203kz
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