PL EN


Preferences help
enabled [disable] Abstract
Number of results
2015 | 128 | 5 | 901-904
Article title

Application of HPLC-MS with Electrospray Ionization for the Qualitative and Quantitative Analysis of Antibiotics in Pharmaceutical Formulation

Content
Title variants
Languages of publication
EN
Abstracts
EN
This study describes the application of electrospray ionization mass spectrometry in order to identify ten antibiotics (macrolides, penicillins, aminoglycosides). An optimum procedure was developed for determination of antibiotics of different grade. Positive ion spectra of most antibiotics are higher in intensity including an [M+H]⁺ ion and produce less fragmentation and are more informative compared to the negative ion spectra. The group of antibiotics exhibits the same characteristic fragmentation. The data base was developed for identification of antibiotics comparing of their molecular and fragment ions. The results of the study showed that the method with electrospray ionization is simple and quick which is useful in the routine determination of antibiotics and in their pharmaceutical dosage forms.
Keywords
EN
Year
Volume
128
Issue
5
Pages
901-904
Physical description
Dates
published
2015-11
References
  • [1] K. Benkenstock, Ph.D. Thesis, KTH, Royal Institute of Technology, Stockholm, Sweden 2008
  • [2] M. Narayanam, T. Handa, P. Sharma, S. Jhajra, P.K. Muthe, P.K. Dappili, R.P. Shah, S. Singh, J. Pharmaceut. Biomed. Anal. 87, 191 (2014), doi: 10.1016/j.jpba.2013.04.027
  • [3] E. Nägele, R. Moritz, J. Am. Soc. Mass Spectrom. 16, 1670 (2005), doi: 10.1016/j.jasms.2005.06.002
  • [4] G. Deng, G. Sanyal, J. Pharmaceut. Biomed. Anal. 40, 528 (2006), doi: 10.1016/j.jpba.2005.08.038
  • [5] Xiao-Meng Chong, Chang-Qin Hu, Chromatographia 68, 759 (2008), doi: 10.1365/s10337-008-0790-4
  • [6] R.F. Straub, R.D. Voyksner, J. Chromatography 647, 167 (1993), doi: 10.1016/0021-9673(93)83336-Q
  • [7] R. Nageswara Rao, N. Venkateswarlu, R. Narsimha, J. Chromatography A 1187, 151 (2008), doi: 10.1016/j.chroma.2008.02.021
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-appv128n523kz
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.