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2015 | 127 | 5 | 1516-1519
Article title

Heavy Ion Beams for Radiobiology: Dosimetry and Nanodosimetry at HIL

Content
Title variants
Languages of publication
EN
Abstracts
EN
Ionizing radiation induces a variety of DNA lesions, including single and double strand breaks. Large energy deposition precisely localized along the ion track that occurs in the case of heavy ion irradiation can lead to complex types of DNA double strand breaks in exposed biological material. The formation of nuclear double strand breaks triggers phosphorylation of histone H2AX, which can be microscopically visualized as foci in the γ-H2AX assay. Studies with a carbon ion beam are being carried out at the Heavy Ion Laboratory of the University of Warsaw. The γ-H2AX assay as a method of measuring the biological response of cells irradiated with ^{12}C ions as well as the frequency cluster size distributions obtained in the nanodosimetry experiment at HIL will be presented.
Keywords
EN
Publisher

Year
Volume
127
Issue
5
Pages
1516-1519
Physical description
Dates
published
2015-05
Contributors
  • Heavy Ion Laboratory, University of Warsaw, L. Pasteura 5A, 02-093 Warsaw, Poland
  • Faculty of Physics, University of Warsaw, L. Pasteura 5, 02-093 Warsaw, Poland
author
  • National Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock-Świerk, Poland
author
  • Institute of Physics, Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland
  • Holycross Cancer Center, Artwińskiego 3, 25-734 Kielce, Poland
author
  • Institute of Physics, Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland
  • Holycross Cancer Center, Artwińskiego 3, 25-734 Kielce, Poland
author
  • Institute of Physics, Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland
author
  • National Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock-Świerk, Poland
author
  • National Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock-Świerk, Poland
author
  • Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland
  • Institute of Rural Health, K. Jaczewskiego 2, 20-090 Lublin, Poland
author
  • Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland
  • Institute of Biology, Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland
author
  • Institute of Biology, Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland
author
  • Faculty of Physics, University of Warsaw, L. Pasteura 5, 02-093 Warsaw, Poland
  • National Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock-Świerk, Poland
author
  • National Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock-Świerk, Poland
  • Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland
  • Heavy Ion Laboratory, University of Warsaw, L. Pasteura 5A, 02-093 Warsaw, Poland
  • Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv127n518kz
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