Heavy Ion Beams for Radiobiology: Dosimetry and Nanodosimetry at HIL

• Authors: U. Kaźmierczak , A. Bantsar , D. Banaś , J. Braziewicz , J. Czub , M. Jaskóła , A. Korman , M. Kruszewski , A. Lankoff , H. Lisowska , M. Pietrzak , S. Pszona , T. Stępkowski , Z. Szefliński , M. Wojewódzka
• Languages of publication: EN

Abstracts

EN

Ionizing radiation induces a variety of DNA lesions, including single and double strand breaks. Large energy deposition precisely localized along the ion track that occurs in the case of heavy ion irradiation can lead to complex types of DNA double strand breaks in exposed biological material. The formation of nuclear double strand breaks triggers phosphorylation of histone H2AX, which can be microscopically visualized as foci in the γ-H2AX assay. Studies with a carbon ion beam are being carried out at the Heavy Ion Laboratory of the University of Warsaw. The γ-H2AX assay as a method of measuring the biological response of cells irradiated with ^{12}C ions as well as the frequency cluster size distributions obtained in the nanodosimetry experiment at HIL will be presented.

Keywords

EN

87.53.Bn; 87.53.-j

Discipline

• 87.53.-j: Effects of ionizing radiation on biological systems
• 87.53.Bn: Dosimetry/exposure assessment

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2015
• Volume: 127
• Issue: 5
• Pages: 1516-1519

Dates

published

2015-05

Contributors

author

U. Kaźmierczak

• Heavy Ion Laboratory, University of Warsaw, L. Pasteura 5A, 02-093 Warsaw, Poland
• Faculty of Physics, University of Warsaw, L. Pasteura 5, 02-093 Warsaw, Poland

author

A. Bantsar

• National Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock-Świerk, Poland

author

D. Banaś

• Institute of Physics, Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland
• Holycross Cancer Center, Artwińskiego 3, 25-734 Kielce, Poland

author

J. Braziewicz

• Institute of Physics, Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland
• Holycross Cancer Center, Artwińskiego 3, 25-734 Kielce, Poland

author

J. Czub

• Institute of Physics, Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland

author

M. Jaskóła

• National Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock-Świerk, Poland

author

A. Korman

• National Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock-Świerk, Poland

author

M. Kruszewski

• Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland
• Institute of Rural Health, K. Jaczewskiego 2, 20-090 Lublin, Poland

author

A. Lankoff

• Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland
• Institute of Biology, Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland

author

H. Lisowska

• Institute of Biology, Jan Kochanowski University, Świętokrzyska 15, 25-406 Kielce, Poland

author

M. Pietrzak

• Faculty of Physics, University of Warsaw, L. Pasteura 5, 02-093 Warsaw, Poland
• National Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock-Świerk, Poland

author

S. Pszona

• National Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock-Świerk, Poland

author

T. Stępkowski

• Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland

author

Z. Szefliński

• Heavy Ion Laboratory, University of Warsaw, L. Pasteura 5A, 02-093 Warsaw, Poland

author

M. Wojewódzka

• Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland

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Identifiers

DOI

10.12693/APhysPolA.127.1516