Synthesis of Endogenous Compounds Labeled with ^{11}C for Positron Emission Tomography

• Authors: K. Kilian , A. Pękal
• Languages of publication: EN

Abstracts

EN

Among the β⁺ emitting isotopes, produced in medical cyclotrons, carbon-11 is promising radionuclide for labeling of biologically active compounds and tracking their distribution in living organism. Therefore aminoacids, carboxylic acids, fatty acids and amines have been widely used in assessing and staging of brain tumors (^{11}C-methionine), prostate cancer (^{11}C-choline, ^{11}C-acetate) and neurological disorders (^{11}C-labeled neurotransmitters). This paper reviews recent achievements in synthesis of endogenous substances labeled with ^{11}C and presents our experience in ^{11}C-methionine synthesis. Proposed protocol is a reliable tool for routine manufacturing in clinical applications and animal studies.

Keywords

EN

87.57.un

Discipline

• 87.57.un: Radiopharmaceuticals

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2015
• Volume: 127
• Issue: 5
• Pages: 1475-1478

Dates

published

2015-05

Contributors

author

K. Kilian

• Heavy Ion Laboratory, University of Warsaw, L. Pasteura 5a, 02-093 Warsaw, Poland

author

A. Pękal

• Heavy Ion Laboratory, University of Warsaw, L. Pasteura 5a, 02-093 Warsaw, Poland

References

• [1] J.W. Fletcher, B. Djulbegovic, H.P. Soares, B.A. Siegel, V.J. Lowe, G.H. Lyman, R.D. Samson, D. Delbeke, M. Gorman, A.F. Shields, E. Coleman, R. Wahl, J.Ch. Paschold, N. Avril, L.H. Einhorn, W.W. Suh, J. Nucl. Med. 49, 480 (2008), doi: 10.2967/jnumed.107.047787
• [2] B. Långrström, F. Karimi, Y. Wantanabe, J. Label Comp. Radiopharm. 56, 251 (2013), doi: 10.1002/jlcr.3033
• [3] C. Pötzi, A. Becherer, C. Marosi, G. Karanikas, M. Szabo, R. Dudczak, K. Kletter, S. Asenbaum, J. Neurooncol. 84, 305 (2007), doi: 10.1007/s11060-007-9375-6
• [4] S. Albrecht, F. Buchegger, D. Soloviev, H. Zadi, H. Vees, H.G. Khan, A. Keller, A.B. Delaloye, O. Ratib, R. Mirabell, Eur. J. Nucl. Med. Mol. Imaging 34, 185 (2007), doi: 10.1007/s00259-006-0163-x
• [5] M. Thambisetty, K.A. Gallardo, J. San Liow, L.L. Beason-Held, J.C. Umhau, A.K. Bhattacharjee, M. Der, P. Herscovitch, J.L. Rapoport, S.I. Rapoport, J. Cereb. Blood. Flow. Metab. 32, 676 (2012), doi: 10.1038/jcbfm.2011.171
• [6] J. Andersson, P. Truong, Ch. Halldin, Appl. Radiat. Isot. 67, 106 (2009), doi: 10.1016/j.apradiso.2008.09.010
• [7] B.H. Mock, C. Brown-Proctor, M.A. Green, B. Stelle, B.E. Glick-Wilson, Q. Zheng, Nucl. Med. Biol. 38, 1135 (2011), doi: 10.1016/j.nucmedbio.2011.05.007
• [8] S. Kealey, A. Gee, P.W. Miller, J. Label Comp. Radiopharm. 57, 195 (2014), doi: 10.1002/jlcr.3150
• [9] Xi. Shao, R. Hoareau, A.C. Runkle, L.J.M. Tluczek, B.G. Hockley, B.D. Henderson, P.J.H. Scott, J. Label Comp. Radiopharm. 54, 819 (2011), doi: 10.1002/jlcr.1937
• [10] N.A. Gomzina, O.F. Kuznetsova, Russ. J. Bioorg. Chem. 37, 191 (2011), doi: 10.1134/s1068162011020051
• [11] V. Gomez, J.D. Gispert, V. Amador, J. Llop, J. Label Comp. Radiopharm. 51, 83 (2008), doi: 10.1002/jlcr.1483
• [12] A.H. Jacobs, A. Thomas, L.W. Kracht, H. Li, C. Dittmar, G. Garlip, N. Galldiks, J.C. Klein, J. Sobesky, R. Hilker, S. Vollmar, K. Herholz, K. Wienhard, W.D. Heiss, J. Nucl. Med. 46, 1948 (2005)
• [13] B. Pirotte, S. Goldman, N. Massager, P. David, D. Wikler, A. Vandesteene, I. Salmon, J. Brotchi, M. Levivier, J. Nucl. Med. 45, 1293 (2004)
• [14] M. Hasebe, K. Yoshikawa, S. Ohashi, S. Toubaru, K. Kawaguchi, J. Sato, J. Mizoe, H. Tsujii, Mol. Imaging Biol. 12, 554 (2010), doi: 10.1007/s11307-010-0318-9
• [15] M. Matsuo, K. Miwa, O. Tanaka, J. Shinoda, H. Nishibori, Y. Tsuge, H. Yano, T. Iwama, S. Hayashi, H. Hoshi, J. Yamada, M. Kanematsu, H. Aoyama, Int. J. Radiat. Oncol. Biol. Phys. 82, 83 (2012), doi: 10.1016/j.ijrobp.2010.09.020
• [16] I. Grassi, C. Nanni, V. Allegri, J.J. Morigi, G.C. Montini, P. Castellucci, S. Fanti, Am. J. Nucl. Med. Mol. Imaging 2, 33 (2012)
• [17] S. Le Helleix, F. Dolle, B. Kuhnast, Appl. Radiat. Isot. 82, 7 (2013), doi: 10.1016/j.apradiso.2013.06.020
• [18] D. Soloviev, C. Tamburella, Appl. Radiat. Isot. 64, 995 (2006), doi: 10.1016/j.apradiso.2006.04.011
• [19] D. Le Bars, M. Malleval, F. Bonnefoi, C. Tourvieille, J. Label Comp. Radiopharm. 49, 263 (2006), doi: 10.1002/jlcr.1024
• [20] European Pharmacopoeia, 8th ed. (8.0), L-Methionine ([11C]methyl) injection and Sodium [11C]Acetate injection
• [21] T. Fukumura, R. Nakao, M. Yamaguchi, K. Suzuki, Appl. Radiat. Isot. 62, 1279 (2004), doi: 10.1016/j.apradiso.2004.04.011

Identifiers

DOI

10.12693/APhysPolA.127.1475