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2015 | 127 | 5 | 1475-1478
Article title

Synthesis of Endogenous Compounds Labeled with ^{11}C for Positron Emission Tomography

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EN
Abstracts
EN
Among the β⁺ emitting isotopes, produced in medical cyclotrons, carbon-11 is promising radionuclide for labeling of biologically active compounds and tracking their distribution in living organism. Therefore aminoacids, carboxylic acids, fatty acids and amines have been widely used in assessing and staging of brain tumors (^{11}C-methionine), prostate cancer (^{11}C-choline, ^{11}C-acetate) and neurological disorders (^{11}C-labeled neurotransmitters). This paper reviews recent achievements in synthesis of endogenous substances labeled with ^{11}C and presents our experience in ^{11}C-methionine synthesis. Proposed protocol is a reliable tool for routine manufacturing in clinical applications and animal studies.
Keywords
EN
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Year
Volume
127
Issue
5
Pages
1475-1478
Physical description
Dates
published
2015-05
Contributors
author
  • Heavy Ion Laboratory, University of Warsaw, L. Pasteura 5a, 02-093 Warsaw, Poland
author
  • Heavy Ion Laboratory, University of Warsaw, L. Pasteura 5a, 02-093 Warsaw, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv127n509kz
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