Determination of Secondary Nanostructure of Model Membrane from Local Fishes for Application in Pharmaceutical Field
Languages of publication
As it is difficult to obtain human stratum corneum for testing the pharmacological effect of the drugs, many researchers have tried to find alternative membrane for this purpose, instead of the human skin. Many animal skins e.g. pig, reptile, or fish skin seem to be suitable for this purpose. Therefore this project will provide more details to help understand more deeply the structure of these alternative skins. This project is focused on the fish skin because such skin can be easily found in Germany. Two different techniques i.e. small and wide angle X-ray scattering (SWAXS) and differential scanning calorimetry (DSC) have been applied for characterization of some local fish skins. The results showed that different skins (i.e. human stratum corneum, pig, shed snake, and fish) showed small differences in SWAXS patterns as well as in DSC thermograms. The drug paracetamol and the surfactant sodium lauryl sulphate can penetrate into the fish skins and they can affect a rearrangement of the inner structure which contains different lipids and proteins. The data are in agreement with those obtained for the shed snake skins in our previous study.
-  N. Wonglertnirant, T. Ngawhirunpat, M. Kumpugdee-Vollrath, Biol. Pharm. Bull. 35(4), 523 (2012), doi: 10.1248/bpb.35.523
-  M. Masson, S.D. Sigfusson, T. Loftsson, Journal of Inclusion Phenomena and Macrocyclic Chemistry 44, 177 (2002), doi: 10.1023/A:1023002931535
-  F. Konradsdottir, T. Loftsson, S.D. Sigfusson, Journal of Pharmacy and Pharmacology 61, 121 (2009), doi: 10.1211/jpp/61.01.0017
Publication order reference