Core-Shell Mechanocomposites of Drugs with Inorganic Oxides and Hydroxides

• Authors: T. Shakhtshneider , S. Myz , E. Boldyreva , A. Nizovskii , Rakesh Kumar
• Languages of publication: EN

Abstracts

EN

The composites of piroxicam and meloxicam with gamma-alumina, aluminium hydroxides (gibbsite and boehmite), alpha and gamma polymorphs of iron(III) oxide having different surface area and morphology were prepared by planetary ball-milling. It has been shown that the initial state of the excipient (specific surface area, particle size and morphology) had a pronounced effect on the formation of the core-shell composites with the drugs and their properties. The X-ray diffraction patterns and IR spectra measured for co-milled samples as well as X-ray photoelectron spectroscopy studies gave evidence that the components of the mixtures interacted with each other and became amorphous, as composites were formed. The drug release from the composites was different as compared with pure drugs, meloxicam and piroxicam behaving differently that can be explained by formation of strong or weak bonds with the active sites of the carriers. In the case of mechanocomposites, the drugs dissolved quickly due to high surface of organic phase in the core-shell composites. The high-porous carriers can serve as the sorbents for the drugs in solution.

Keywords

EN

62.25.-g

Discipline

• 62.25.-g: Mechanical properties of nanoscale systems(for structure of nanoscale systems, see 61.46.-w; for structural transitions in nanoscale materials, see 64.70.Nd; for electronic transport in nanoscale systems, see 73.63.-b)

• Journal: Acta Physica Polonica A
• Year: 2014
• Volume: 126
• Issue: 4
• Pages: 1019-1024

Dates

published

2014-10

Contributors

author

T. Shakhtshneider

• Institute of Solid State Chemistry and Mechanochemistry, SB RAS, Kutateladze Str., 18, Novosibirsk, 630128, Russia
• Novosibirsk State University, Pirogova Str., 2, Novosibirsk, 630090, Russia

author

S. Myz

• Institute of Solid State Chemistry and Mechanochemistry, SB RAS, Kutateladze Str., 18, Novosibirsk, 630128, Russia
• Novosibirsk State University, Pirogova Str., 2, Novosibirsk, 630090, Russia

author

E. Boldyreva

• Institute of Solid State Chemistry and Mechanochemistry, SB RAS, Kutateladze Str., 18, Novosibirsk, 630128, Russia
• Novosibirsk State University, Pirogova Str., 2, Novosibirsk, 630090, Russia

author

A. Nizovskii

• Boreskov Institute of Catalysis, SB RAS, Pr. Lavrentieva, 5, Novosibirsk, 630090, Russia
• Omsk State Technical University, Pr. Mira, 11, Omsk, 644050, Russia

author

Rakesh Kumar

• National Metallurgical Laboratory, Jamshedpur, 831 007, India

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Identifiers

DOI

10.12693/APhysPolA.126.1019