Physico-Chemical and Biological Properties of Arsenic Sulfide (As_{55}S_{45}) Nanosuspension Prepared by Milling

• Authors: Z. Bujňáková , O. Shpotyuk , J. Sedlák , M. Pastorek , E. Turianicová , P. Baláž , A. Ingram
• Languages of publication: EN

Abstracts

EN

Nanosuspension based on melt-quenched arsenic sulfide of nominal As_{55}S_{45} composition was prepared by nanomilling and tested as potential anticancer drug. Polyvinylpyrrolidone was used as steric stabilizer and inhibitor of agglomeration. Individual nanoparticles had average size of 192 nm (determined by photon cross-correlation spectroscopy) and had several times better dissolution ability in comparison with bulk As_{55}S_{45}. Effect of nanomilling is shown to be associated with formation of arsenic sulfide crystalline nanoparticles and free-volume entities located at the interface between nanoparticles and surrounding matrix as it follows from positron annihilation measurements. Cytotoxicity tests were performed using human melanoma cell line Bowes and confirmed high toxicity of the studied nanosuspension.

Keywords

EN

81.20.Wk; 81.05.Kf; 81.07.-b

Discipline

• 81.20.Wk: Machining, milling
• 81.07.-b: Nanoscale materials and structures: fabrication and characterization(for structure of nanoscale materials, see 61.46.-w; for nanostructured materials in electrochemistry, see 82.45.Yz; see also 62.23.-c Structural classes of nanoscale systems in mechanical properties of condensed matter)
• 81.05.Kf: Glasses (including metallic glasses)

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2014
• Volume: 126
• Issue: 4
• Pages: 902-906

Dates

published

2014-10

Contributors

author

Z. Bujňáková

• Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04001 Košice, Slovakia

author

O. Shpotyuk

• Scientific Research Company "Carat", 202, Stryjska Str., Lviv, 79031, Ukraine
• Institute of Physics, Jan Długosz University, al. Armii Krajowej 13/15, 42-200 Częstochowa, Poland

author

J. Sedlák

• Cancer Research Institute, Slovak Academy of Sciences, 7, Vlárska Str., Bratislava, 83391 Slovakia

author

M. Pastorek

• Cancer Research Institute, Slovak Academy of Sciences, 7, Vlárska Str., Bratislava, 83391 Slovakia

author

E. Turianicová

• Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04001 Košice, Slovakia

author

P. Baláž

• Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04001 Košice, Slovakia

author

A. Ingram

• Opole University of Technology, Ozimska 75, 45-370 Opole, Poland

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Identifiers

DOI

10.12693/APhysPolA.126.902