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2014 | 126 | 4 | 902-906
Article title

Physico-Chemical and Biological Properties of Arsenic Sulfide (As_{55}S_{45}) Nanosuspension Prepared by Milling

Content
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EN
Abstracts
EN
Nanosuspension based on melt-quenched arsenic sulfide of nominal As_{55}S_{45} composition was prepared by nanomilling and tested as potential anticancer drug. Polyvinylpyrrolidone was used as steric stabilizer and inhibitor of agglomeration. Individual nanoparticles had average size of 192 nm (determined by photon cross-correlation spectroscopy) and had several times better dissolution ability in comparison with bulk As_{55}S_{45}. Effect of nanomilling is shown to be associated with formation of arsenic sulfide crystalline nanoparticles and free-volume entities located at the interface between nanoparticles and surrounding matrix as it follows from positron annihilation measurements. Cytotoxicity tests were performed using human melanoma cell line Bowes and confirmed high toxicity of the studied nanosuspension.
Keywords
EN
Contributors
  • Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04001 Košice, Slovakia
author
  • Scientific Research Company "Carat", 202, Stryjska Str., Lviv, 79031, Ukraine
  • Institute of Physics, Jan Długosz University, al. Armii Krajowej 13/15, 42-200 Częstochowa, Poland
author
  • Cancer Research Institute, Slovak Academy of Sciences, 7, Vlárska Str., Bratislava, 83391 Slovakia
author
  • Cancer Research Institute, Slovak Academy of Sciences, 7, Vlárska Str., Bratislava, 83391 Slovakia
  • Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04001 Košice, Slovakia
author
  • Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04001 Košice, Slovakia
author
  • Opole University of Technology, Ozimska 75, 45-370 Opole, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv126n409kz
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