Studies on Catalase-Like Activity of Some Tc-99m Radiopharmaceuticals

• Authors: E. Çıçek , B. Dede
• Languages of publication: EN

Abstracts

EN

Hydrogen peroxide is an ubiquitous metabolite in living systems, produced at increased levels in a variety of pathological situations. Therefore suppressing or at least controlling H_2O_2 production is important. Catalase enzymes can convert hydrogen peroxide into water and dioxygen and a similar role can be played by transition metal ions or some radiopharmaceuticals. (1) TcO_4^-, (2) Tc-99m mercaptoacetyltriglycine (MAG3) and (3) Tc-99m methoxyisobutylisonitrile (MIBI) were each tested for their ability to catalyse the disproportionation of hydrogen peroxide in the presence of the added base imidazole. It was found that (2) and (3) exhibit acceptable catalase-like activity compared to the Tc-99m pertechnetate.

Keywords

EN

87.57.uk

Discipline

• 87.57.uk: Positron emission tomography (PET)

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2014
• Volume: 125
• Issue: 4
• Pages: 875-876

Dates

published

2014-04

Contributors

author

E. Çıçek

• Faculty of Science and Art, Mehmet Akif Ersoy University, Burdur, Turkey

author

B. Dede

• Faculty of Science and Art, Süleyman Demirel University, Isparta, Turkey

References

• [1] U. Eberlein, J.H. Bröer, C. Vandevoorde, P. Santos, M. Bardiès, K. Bacher, D. Nosske, M. Lassmann, Eur. J. Nucl. Med. Mol. Imaging 38, 2269 (2011), doi: 10.1007/s00259-011-1904-z
• [2] H. Wang, W. Jiang, Y. Wang, X. Liu, J. Yao, L. Yuan, Z. Wu, D. Li, B. Song, H. Chen, Langmuir 29, 3 (2013), doi: 10.1021/la304378w
• [3] H. Okamoto, K. Horii, A. Fujisawa, Y. Yamamoto, Exp. Dermatol. 1, 5 (2012), doi: 10.1111/j.1600-0625.2012.01494.x
• [4] R. Joshi, S.N. Limye, Oxidn. Commun. 21, 337 (1998)
• [5] I. Mochida, K. Takeshita, J. Phys. Chem. 78, 1653 (1974), doi: 10.1021/j100609a011

Identifiers

DOI

10.12693/APhysPolA.125.875