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2014 | 125 | 4 | 875-876
Article title

Studies on Catalase-Like Activity of Some Tc-99m Radiopharmaceuticals

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Content
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EN
Abstracts
EN
Hydrogen peroxide is an ubiquitous metabolite in living systems, produced at increased levels in a variety of pathological situations. Therefore suppressing or at least controlling H_2O_2 production is important. Catalase enzymes can convert hydrogen peroxide into water and dioxygen and a similar role can be played by transition metal ions or some radiopharmaceuticals. (1) TcO_4^-, (2) Tc-99m mercaptoacetyltriglycine (MAG3) and (3) Tc-99m methoxyisobutylisonitrile (MIBI) were each tested for their ability to catalyse the disproportionation of hydrogen peroxide in the presence of the added base imidazole. It was found that (2) and (3) exhibit acceptable catalase-like activity compared to the Tc-99m pertechnetate.
Keywords
EN
Publisher

Year
Volume
125
Issue
4
Pages
875-876
Physical description
Dates
published
2014-04
Contributors
author
  • Faculty of Science and Art, Mehmet Akif Ersoy University, Burdur, Turkey
author
  • Faculty of Science and Art, Süleyman Demirel University, Isparta, Turkey
References
  • [1] U. Eberlein, J.H. Bröer, C. Vandevoorde, P. Santos, M. Bardiès, K. Bacher, D. Nosske, M. Lassmann, Eur. J. Nucl. Med. Mol. Imaging 38, 2269 (2011), doi: 10.1007/s00259-011-1904-z
  • [2] H. Wang, W. Jiang, Y. Wang, X. Liu, J. Yao, L. Yuan, Z. Wu, D. Li, B. Song, H. Chen, Langmuir 29, 3 (2013), doi: 10.1021/la304378w
  • [3] H. Okamoto, K. Horii, A. Fujisawa, Y. Yamamoto, Exp. Dermatol. 1, 5 (2012), doi: 10.1111/j.1600-0625.2012.01494.x
  • [4] R. Joshi, S.N. Limye, Oxidn. Commun. 21, 337 (1998)
  • [5] I. Mochida, K. Takeshita, J. Phys. Chem. 78, 1653 (1974), doi: 10.1021/j100609a011
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv125n405kz
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