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2012 | 121 | 5-6 | 1305-1307
Article title

Presence of Magnetic Fluids Leads to the Inhibition of Insulin Amyloid Aggregation

Content
Title variants
Languages of publication
EN
Abstracts
EN
Insulin amyloid aggregation caused serious problems in the treatment of diabetes by insulin injection or by insulin pumps. In vitro formation of insulin amyloid fibrils was investigated in presence of several types of magnetic fluids. Interaction of magnetic fluids with insulin amyloid aggregates led to decrease of insulin fibrillization. The inhibiting activities are affected by coating layer of studied magnetic fluids as well as by their physical properties (diameter, concentration of magnetic particles). The highest inhibiting efficiencies were detected for sterically stabilized magnetic fluids in saline solution (75%) and for magnetic fluids modified by dextran (80%).
Keywords
EN
Publisher

Year
Volume
121
Issue
5-6
Pages
1305-1307
Physical description
Dates
published
2012-05
Contributors
author
  • Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
author
  • Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
  • Department of Biochemistry, Faculty of Science, Safarik University, Kosice, Slovakia
author
  • Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
author
  • Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
author
  • Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
  • Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
author
  • Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
author
  • Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
  • Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
author
  • Institute of Biology and Ecology, Faculty of Science, Safarik University, Kosice, Slovakia
author
  • Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
References
  • 1. J.D. Sipe, Amyloid Proteins, Wiley-VCH, Weinheim 2005
  • 2. D.M. Walsh, D.J. Selkoe, Protein Pept. Lett. 11, 213 (2004)
  • 3. S.S.-S. Wang, K.-N. Liu, T.-C. Han, Biochim. Biophys. Acta Mol. Basis Dis. 1802, 519 (2010)
  • 4. M. Kanapathipillai, S.H. Ku, K. Girigoswami, Ch.B. Park, Biochem. Biophys. Res. Com. 365, 808 (2008)
  • 5. A. Bellova, E. Bystrenova, M. Koneracka, P. Kopcansky, F. Valle, M. Timko, J. Bagelova, F. Biscarini, Z. Gazova, Nanotechnology 21, 065103 (2010)
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv121n5-6p98kz
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