Structural Changes of DPPC Bilayers Induced by Gemini Surfactant

• Authors: W. Kida , M. Kozak
• Languages of publication: EN

Abstracts

EN

The phospholipid-gemini surfactant systems are promising agents for construction of lipoplexes for DNA delivery systems in gene therapy. In this work the influence of a gemini surfactant - 1,1'-(1,6-hexan)bis3-octyloxymethylimidazolium di-chloride) (IMI_Cl_C6_C8) on the structure and phase behaviour of aqueous suspensions of the fully hydrated phospholipid - 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were characterised using small angle scattering of synchrotron radiation (SAXS), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The surfactant studied caused a destabilisation of the lamellar phase typical of DPPC. Addition of the surfactant also shifted to lower temperatures and extended the range of the main phase transition

Keywords

EN

87.15.Zg; 61.05.cf; 87.64.km; 87.16.dt

Discipline

• 87.16.dt: Structure, static correlations, domains, and rafts
• 87.64.km: Infrared
• 87.15.Zg: Phase transitions
• 61.05.cf: X-ray scattering (including small-angle scattering)

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2012
• Volume: 121
• Issue: 4
• Pages: 893-898

Dates

published

2012-04

Contributors

author

W. Kida

• Departament of Macromolecular Physics, Faculty of Physics, A. Mickiewicz University, Umultowska 85, 61-614 Poznań, Poland

author

M. Kozak

• Departament of Macromolecular Physics, Faculty of Physics, A. Mickiewicz University, Umultowska 85, 61-614 Poznań, Poland

References

• 1. H. Heerklotz, Q. Rev. Biophys. 41, 205 (2008)
• 2. S. Jain, P. Jain, R.B. Umamaheshwari, N.K. Jain, Drug Dev. Ind. Pharm. 29, 1013 (2003)
• 3. M.J. Lawrence, G.D. Rees, Adv. Drug Deliv. Rev. 45, 89 (2000)
• 4. M. Kreilgaard, Adv. Drug Deliv. Rev. 54, S77 (2002)
• 5. D.E. Warschawski, A.A. Arnold, M. Beaugrand , A. Gravel, É. Chartrand, I. Marcotte, Biochim. Biophys. Acta-Biomembr. 1808, 1957 (2011)
• 6. M. Caffrey, Annu. Rev. Biophys. 38, 29 (2009)
• 7. R. Zana, in: Novel Surfactants: Preparation, Applications and Biodegradability, M. Dekker Inc, New York (1998)
• 8. F.M. Menger, C.A. Littau, J. Am. Chem. Soc. 113, 1451 (1991)
• 9. R. Zana, M. Benrraou, R. Rueff, Langmuir 7, 1072 (1991)
• 10. H.C. Parreira, E.R. Lukenbach, M.K. Lindemann, J. Am. Oil Chem. Soc. 56, 1015 (1979)
• 11. C.A. Bunton, L. Robinson, J. Schaak, M.F. Stam, J. Org. Chem. 36, 2346 (1971)
• 12. M. Frindi, B. Michels, H. L'evy, R. Zana, , Langmuir 10, 1140 (1994)
• 13. R. Zana, Gemini Surfactants: Synthesis, Interfacial and Solution-Phase Behavior, and Applications, CRC Press (2003)
• 14. R. Zana, Adv. Colloid Interface Sci. 97, 205 (2002)
• 15. M. Pavlikova, I. Lacko, F. Devinsky, D. Mlynarcik, Collect. Czech. Chem. Commun. 60, 1213 (1995)
• 16. M. Dubnickova, M. Pisarcik, I. Lacko, F. Devinsky, Cell. Mol. Biol. Lett. 2, 215 (1997)
• 17. S. Svenson, Curr. Opin. Colloid Interface Sci. 9, 201 (2004)
• 18. C. Bombelli, L. Giansanti, P. Luciani, G. Mancini, Curr. Med. Chem. 16, 171 (2009)
• 19. S.K. Hait, S.P. Moulik, Curr. Sci. 82, 1101 (2002)
• 20. D. Blunk, P. Bierganns, N. Bongartz, R. Tessendorf, C. Stubenrauch, New J. Chem. 30, 1705 (2006)
• 21. Z. Pietralik, M. Taube, A. Skrzypczak, M. Kozak, Acta Phys. Polon. A 117, 311 (2010)
• 22. Á. Csiszár, E. Klumpp, A. Bota, K. Szegedi, Chem. Phys. Lipids 126, 155 (2003)
• 23. M. Knaapila, C. Svensson, J. Barauskas, M. Zackrisson, S.S. Nielsen, N. Nørgaard Toft, B. Vestergaard, L. Arleth, Y. Cerenius, J. Synch. Rad. 16, 498 (2009)
• 24. T.C. Huang, H. Toraya, T.N. Blanton, Y. Wu, J. Appl. Cryst. 26, 180 (1993)
• 25. P.V. Konarev, V.V. Volkov, A.V. Sokolova, M.H.J. Koch, D.I. Svergun, J. Appl. Cryst. 36, 1277 (2003)
• 26. M. Rappolt, G. Pabst, G. Rapp, M. Kriechbaum, H. Amenitsch, Ch. Krenn, S. Bernstorff, P. Laggner, Eur. Biophys. J. 29, 125 (2000)
• 27. T. Mavromoustakos, E. Theodoropoulou, D. Papahatjis, T. Kourouli, ve-Ping Yang, M. Trumbore, A. Makriyannis, Biochim. Biophys. Acta-Biomembr. 1281, 235 (1996)
• 28. B. Carion-Taravella, S. Lesieur, J. Chopineau, P. Lesieur, M. Ollivon. Langmuir 18, 325 (2002)
• 29. E. Soussan, M. Blanzat, I. Rico-Lattes, A. Brun, C.V. Teixeira, G. Brezesinski, F. Al-Ali, A. Banu, M. Tanaka, Colloid Surf. A -Physicochem. Eng. Asp. 303, 55 (2007)
• 30. M. Kozak, L. Domka, S. Jurga, J. Therm. Anal. Calorim. 88, 395 (2007)
• 31. J. Bolze, T. Fujisawa, T. Nagao, K. Norisada, N. Saito, A. Naito, Chem. Phys. Lett. 329, 215 (2000)
• 32. P. Laggner, J.D. Gotto, J.D. Morrisett, Biochemistry 18, 164 (1979)
• 33. M. Kozak, M. Kempka, K. Szpotkowski, S. Jurga, J. Non-Cryst. Solids 353, 4246 (2007)
• 34. S.W. Huffman, S. Schlucker, I.W. Levin, Chem. Phys. Lipids 130, 167 (2004)
• 35. H. Boyar, F. Severcan J. Mol. Struct. 408/409, 269 (1997)
• 36. F. Severcan, I. Sahin, N. Kazanci, Biochim. Biophys. Acta-Biomembr. 1668, 215 (2005)
• 37. M. Kozak, K. Szpotkowski, A. Kozak, R. Zieliński, D. Wieczorek, M.J. Gajda, L. Domka, Radiat. Phys. Chem. 78, S129 (2009)
• 38. X. Zhai, M. Bartel, G. Brezesinski, B. Rattay, H. Mohwald, J. Li. Chem. Phys. Lipids 133, 79 (2005)
• 39. R. Koynova, M. Caffrey, Biochim. Biophys. Acta 1376, 91 (1998)
• 40. C. Matsingou, C. Demetzos, Chem. Phys. Lipids 145, 45 (2007)
• 41. M. Kozak, K. Szpotkowski, A. Kozak, R. Zielinski, D. Wieczorek, M.J. Gajda, Radiat. Phys. Chem. 78, S112 (2009)

Identifiers

DOI

10.12693/APhysPolA.121.893