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2012 | 121 | 4 | 866-870
Article title

Status and Vision for Structural Biology at the Canadian Light Source

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The status and vision for Structural Biology at the Canadian Light Source (CLS) is presented. The beamlines that have been described in the paper represent a Canadian national resource that is available to science and industry world-wide. They include state-of-the-art infrastructure and include specialized capabilities, many of which are not available elsewhere, including macromolecular crystallography, biological X-ray spectroscopy, soft X-ray spectromicroscopy, as well as small angle and wide angle X-ray scattering beamlines. The vision for Structural Biology at the Canadian Light Source is significantly enhanced by the synergies and collaborations between the users of the different beamlines and by the strengths of the scientific personnel and trainees.
Physical description
  • Canadian Light Source, 101 Perimeter Road, Saskatoon, SK S7N 0X4 Canada
  • College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C8, Canada
  • Canadian Light Source, 101 Perimeter Road, Saskatoon, SK S7N 0X4 Canada
  • Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, Saskatoon SK S7N 5E5, Canada
  • Department of Geology, University of Saskatchewan, 114 Science Place, Saskatoon, SK S7N 5E2, Canada
  • 1. A. Kuller, W. Fleri, W.F. Bluhm, J.L. Smith, J. Westbrook, P.E. Bourne, Trends in Biochemical Sciences 23, 213 (2002)
  • 2. P. Grochulski, M.N. Fodje, J. Gorin, S.L. Labiuk, R. Berg, J. Synchrotron Rad. 18, 681 (2011)
  • 3. M.N. Fodje, K. Janzen, R. Berg, G. Black, S. Labiuk, J. Gorin, P. Grochulski, J. Synchrotron Rad. 19, 274 (2012)
  • 4. M.N. Fodje, R. Berg, G. Black, P. Grochulski, K. Janzen, Automation of the Macromolecular Crystallography Beamlines at the Canadian Light Source, PCaPAC, Saskatoon (2010)
  • 5. W. Kabsch, Journal of Appl. Crystallogr. 26, 795 (1993)
  • 6. P.R. Evans, Acta Cryst. D62, 72 (2006)
  • 7. N.4. Collaborative Computational Project, Acta Cryst. 50, 760 (1994)
  • 8. G.P. Bourenkov, A.N. Popov, Acta Cryst. D62, 58 (2006)
  • 9. K. Diederichs, Acta Cryst. D62, 96 (2006)
  • 10. M.L. Tonkin, M. Roques, M.H. Lamarque, M. Pugničre, D. Douguet, J. Crawford, M. Lebrun, M.J. Boulanger, Science 333, 463 (2011)
  • 11. M.A. DePristo, P.I. deBakker, T.L. Blundell, Structure 12, 831 (2004)
  • 12. M.J. Pushie, G.N. George, Coord. Chem. Rev. 255, 1055 (2011)
  • 13. B.F.G. Popescu, M.J. George, U. Bergmann, A.V. Garachtchenko, M.E. Kelly, R.P.E. McCrea, K. Lüning, R.M. Devon, G.N. George, A.D. Hanson, S.M. Harder, L.D. Chapman, I.J. Pickering, H. Nichol, Phys. Med. Biol. 54, 651 (2009)
  • 14. L. Zhang, J. Lichtmannegger, K.H. Summer, S. Webb, I.J. Pickering, G.N. George, Biochemistry 48, 891 (2009)
  • 15. K.V. Kaznatcheev, C.Ch. Karunakaran, U.D. Lanke, S.G. Urquhart, M. Obst, A. Hitchcock, Nucl. Inst. Meth. 582, 96 (2007)
  • 16. K.P. Lam, A.P. Hitchcock, M. Obst, J.R. Lawrence, G.D.W. Swerhone, G.G. Leppard, T. Tyliszczak, C. Karunakaran, J. Wang, K. Kaznatcheev, D.A. Bazylinski, U. Lins, Chemical Geology 270, 110 (2010)
  • 17. G.L Hura, L.A. Menon, M. Hammel, R. Rambo, L.F. Poole II, S.E. Tsutakawa, F. Jenney Jr, S. Classen, K. Frankel, R. Hopkins, S. Yang, J. Scott, B. Dillard, M. Adams, J.A. Tainer, Nature Methods 6, 606 (2009)
  • 18. T.D. Grant, J.R. Luft, J.R. Wolfley, H. Tsuruta, A. Martel, G.T. Montelione, E. Snell, Biopolymers 95 , 517 (2011)
  • 19. M. Cammarata, M. Levantino, F. Schotte, P.A. Anfinrud, F. Ewald, J. Choi, A. Cupane, M. Wulff, H. Ihee, Nature Methods 5, 881 (2008)
  • 20. C. Leal, N.F. Bouxsein, K.K. Ewert, C.R. Safinya, J. Am. Chem. Soc 132, 16841 (2010)
  • 21. Y. Dong, B.J. Boyd, Int. J. Pharm. 417, 101 (2011)
  • 22. M.J. Pushie, I.J. Pickering, G.R. Martin, S. Tsutsui, F.R. Jirik, G.N. George, Metallomics 3, 206 (2011)
  • 23. K.E. van Straaten, H. Zheng, D.R. Sanders, D. Palmer, Biochem. J. 432, 237 (2010)
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