Nanocomposite Polymer Scaffolds for Bone Tissue Regeneration

• Authors: E. Stodolak-Zych , A. Frączek-Szczypta , A. Wiecheć , M. Błażewicz
• Languages of publication: EN

Abstracts

EN

Nanocomposite polymer scaffolds for tissue engineering were prepared using leaching method. As a porogen there were used phosphate salts with different grain size (100-400 μm). Nanocomposite materials based on polylactide (PL/DLA) containing 2 wt% of ceramic bioactive nanoadditives (SiO_2) were prepared. The nanoadditive was characterized by dynamic light scatering (DLS) (size) and the Brunauer-Emmett-Teller (specific surface area) methods. Morphology of the nanoparticles was observed using the transmission electron microscopy. The optimal concentration of the nanofiller in the polymer matrix was evaluated on the basis of in vitro tests of the nanocomposite foils contacted with osteoblast-like human cells of MG63 line. The morphology and porosity of the scaffold after leaching was evaluated using scanning electron microscopy and hydrostatic weighing. The bioactivity test made on the scaffolds demonstrated ability to nucleation of apatite structure on the material.

Keywords

EN

82.35.Np

Discipline

• 82.35.Np: Nanoparticles in polymers(see also 81.07.-b Nanoscale materials and structures: fabrication and characterization)

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2012
• Volume: 121
• Issue: 2
• Pages: 518-521

Dates

published

2012-02

Contributors

author

E. Stodolak-Zych

• Faculty of Material Science and Ceramic, Department of Biomaterials, AGH-University of Science and Technology, Kraków, Poland

author

A. Frączek-Szczypta

• Faculty of Material Science and Ceramic, Department of Biomaterials, AGH-University of Science and Technology, Kraków, Poland

author

A. Wiecheć

• The Henryk Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland

author

M. Błażewicz

• Faculty of Material Science and Ceramic, Department of Biomaterials, AGH-University of Science and Technology, Kraków, Poland

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Identifiers

DOI

10.12693/APhysPolA.121.518