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2012 | 121 | 2 | 468-473
Article title

Langmuir Monolayer Characteristics of Erucylphosphocholine - A Novel Anti-Tumor Drug

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EN
Abstracts
EN
Erucylphosphocholine, an alkylphosphocholine anticancer drug, was employed for Langmuir monolayer characterization and liquid crystalline studies. Differential scanning calorimetry measurements together with texture observation with polarizing microscope revealed the presence of nematic phase. Film forming properties of erucylphosphocholine at the air/water interface were thoroughly investigated by means of surface pressure-area (π-A) and electric surface potential-area (Δ V-A) isotherms. The influence of such factors as subphase temperature, ionic strength, speed of compression, number of molecules spread at the surface on the characteristics of the π-A isotherms was investigated. Erucylphosphocholine was found to form very stable Langmuir monolayers, which are almost not influenced by experimental conditions. The liquid character of its monolayers was confirmed with both compressibility modulus values and homogeneous Brewster angle microscopy images.
Keywords
EN
Publisher

Year
Volume
121
Issue
2
Pages
468-473
Physical description
Dates
published
2012-02
Contributors
author
  • Institute of Physics, Jagiellonian University, W.S. Reymonta 4,30-059 Kraków, Poland
author
  • Institute of Physics, Jagiellonian University, W.S. Reymonta 4,30-059 Kraków, Poland
author
  • Institute of Physics, Jagiellonian University, W.S. Reymonta 4,30-059 Kraków, Poland
  • Faculty of Chemistry, Jagiellonian University, R. Ingardena 3, 30-060 Kraków, Poland
References
  • [1] W.E. Berdel, R. Andreesen, P.G. Munder, J.F. Kuto, CRC Press 2, 41 (1985)
  • [2] C. Long, R. Odavio, E.J. Sargent, Biochem J. 102, 221 (1967)
  • [3] A.R. Poole, J.I. Howell, J.A. Lucy, Nature 227, 810 (1970)
  • [4] D.L. Dick, D.S. Lawrence, Biochemistry 31, 8252 (1992)
  • [5] G.A. Ruiter, S.F. Zerp, H. Bartelink, Cancer Res. 15, 2457 (1999)
  • [6] C. Gajate, F. Mollinedo, Curr. Drug Metab. 3, 491 (2002)
  • [7] C. Unger, E.A.M. Fleer, J. Kötting, W. Neumüller, H. Eibl, Prog. Exp. Tumor Res. 34, 25 (1992)
  • [8] H. Eibl, C. Unger, Cancer Treat Rev. 17, 233 (1990)
  • [9] A.H. van der Luit, S.R. Vink, J.B. Klarenbeek, D. Perrissoud, E. Solary, M. Verheij, W.J. Blitterswijk, Mol. Cancer Ther. 6, 2337 (2007)
  • [10] A. Rübel, R. Handrick, L.H. Lindner, M. Steiger, H. Eibl, W. Budach, C. Belka, V. Jendrossek, Radiat. Oncol. 1, 6 (2006)
  • [11] S.M. Konstantinov, H. Biel, M.R. Berger, Br. J. Haematol. 107, 365 (1999)
  • [12] R. Aveyard, R. Haidon, An Introduction to the Principles of Surface Chemistry, Cambridge University Press, London 1973
  • [13] G. Arthur, R. Bittman, Biochim. Biophys. Acta 1390, 85 (1988)
  • [14] V. Jendrossek, R. Handrick, Curr. Med. Chem. - Anti-Cancer Agents 3, 343 (2003)
  • [15] E.E. Kelley, E.J. Modest, C.P. Burns, Biochem. Pharmacol. 22, 2435 (1992)
  • [16] G.L. Gaines Jr., Insoluble Monolayers at Liquid-Gas Interfaces, Interscience Publishers, New York 1966
  • [17] K. Hąc-Wydro, P. Dynarowicz-Łątka, Annales UMCS, Ser. AA (Chemia) 63, 47 (2008)
  • [18] M.R. Berger, S. Sobottka, S.M. Konstantinov, H. Eibl, Drugs Today 34, 73 (1998)
  • [19] W. Kugler, B. Erdlenbruch, A. Jünemann, D. Heinemann, H. Eibl, M. Lakomek, J. Neurochem. 82, 1160 (2002)
  • [20] W. Kugler, F. Bucholtz, F. Köhler, H. Eibl, M. Lakomek, B. Erdlenbruch, Apoptosis 10, 1163 (2005)
  • [21] M.P. Carraseo, J.M. Jiménez-López, P. Rios-Marco, J.L. Segovia, C. Marco, Br. J. Pharmacol. 160, 355 (2010)
  • [22] N. Takai, T. Ueda, K. Nasu, H. Narahara, Gynecol. Oncol. 111, 336 (2008)
  • [23] H. Eibl, P. Hilgard, C. Unger, Alkylphosphocholines: New Drugs in Cancer Therapy, Kargel, Basel 1992
  • [24] H. Theorell, E. Stenhagen, Biochem. Z. 299, 417 (1939)
  • [25] J.T. Davies, E.K. Rideal, Interfacial Phenomena, Academic Press, New York 1963
  • [26] I. Rey Gómez-Serranillos, J. Miñones Jr, P. Dynarowicz-Łątka, E. Iribarnegaray, M. Casas, Phys. Chem. Chem. Phys. 6, 1580 (2004)
  • [27] V.B.P. Leite, A. Cavalli, O.N. Oliveira, Jr., Phys. Rev. E. 57, 6835 (1998)
  • [28] O.N. Oliveira, Jr., D.M. Taylor, H. Morgan, Thin Solid Films 7, 210 (1992)
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv121n266kz
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