Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hydrogel Hybrids

• Authors: J. Jovašević , S. Dimitrijević , J. Filipović , S. Tomić , M. Mićić , E. Suljovrujić
• Languages of publication: EN

Abstracts

EN

A simple and fast approach to the design and production of new hybrid polymeric biomaterials with silver particles is presented in this work. Silver/semi-interpenetrating network hybrid hydrogels (Ag/semi-IPNHHs) were prepared through an optimized solution crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), in the presence of PVP, a silver salt and a reducing "green" agent (Ag/P(HEMA/IA)/PVP). PVP was chosen due to its protective, reduction, and nucleation properties in the production of metal particles. The structure of the Ag/semi-IPNHH was characterized by Fourier transform infrared spectroscopy (FTIR). The presence of silver and PVP in the network was confirmed by FTIR spectra. The results obtained by dynamic mechanical analysis (DMA) showed good mechanical properties for all samples. The swelling studies of Ag/P(HEMA/IA)/PVP were conducted in the temperature range of 25-55°C, in the buffer of pH 7.40. The Ag/semi-IPNHH showed temperature-sensitive swelling properties, with the lower critical solution temperature (LCST) values in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus and C. albicans pathogens. It was concluded that the antimicrobial potential depends on the hydrogel's composition and the type of microbes

Keywords

EN

36.20.Fz; 82.35.Jk; 81.05.Qk; 81.05.Lg; 61.25.hp; 82.35.-x; 62.20.-x; 81.70.Bt

Discipline

• 61.25.hp: Polymer swelling, cross linking
• 62.20.-x: Mechanical properties of solids
• 81.05.Lg: Polymers and plastics; rubber; synthetic and natural fibers; organometallic and organic materials(for polymers and organic materials in electrochemistry, see 82.45.Wx)
• 82.35.-x: Polymers: properties; reactions; polymerization(for polymers in electrochemistry, see 82.45.Wx)
• 81.05.Qk: Reinforced polymers and polymer-based composites
• 82.35.Jk: Copolymers, phase transitions, structure
• 81.70.Bt: Mechanical testing, impact tests, static and dynamic loads(see also 62.20.M- Structural failure of materials; 46.50.+a Fracture mechanics, fatigue, and cracks)
• 36.20.Fz: Constitution (chains and sequences)

• Journal: Acta Physica Polonica A
• Year: 2011
• Volume: 120
• Issue: 2
• Pages: 279-283

Dates

published

2011-08

Contributors

author

J. Jovašević

• Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia

author

S. Dimitrijević

• Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia

author

J. Filipović

• Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia

author

S. Tomić

• Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia

author

M. Mićić

• Vinca Institute of Nuclear Sciences, 11001 Belgrade, Serbia

author

E. Suljovrujić

• Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia

References

• 1. R. Kumar, H. Munstedt, Biomaterials 26, 2081 (2005)
• 2. S. Khare, M. Moneke, R. Hempelmann, N. Plachkov, M. Bureik, N. Lenz, Proceedings of the 63rd Annual Technical Conference (ANTEC 2005, Boston 2005), p. 1295
• 3. S.K. Bajpai, Y.M. Mohan, M. Bajpai, R. Tankhiwale, V. Thomas, J. Nanosc. Nanotechn. 7, 2994 (2007)
• 4. A. Vaseashta, D. Dimova-Malinovska, Sci. Techn. Adv. Mat. 6, 312 (2005)
• 5. D. Singh, V. Choudhary, V. Koul, J. Appl. Polym. Sci. 104, 1456 (2007)
• 6. S. Kadlubowski, A. Henke, P. Ulanski, J.M. Rosiak, L. Bromberg, T.A. Hatton, Polymer 48, 4974 (2007)
• 7. J.M. Rosiak, P. Ulanski, Radiat. Phys. Chem. 55, 139 (1999)
• 8. S. Vijayasekaran, T.V. Chirila, Y. Hong, S.G. Tahija, P.D. Dalton, I.J. Constable, I.L. McAllister, J. Biomater. Sci: Polym. Ed. 7, 685 (1996)
• 9. M.M. Faragalla, D.J.T. Hill, A.K. Whittaker, Polym. Bull. 47, 421 (2002)
• 10. D.L. Perera, R.A. Shank, Polym. Int. 39, 121 (1996)
• 11. K. Na, K.H. Park, Biotechnol. Lett. 22, 1553 (2000)
• 12. D.J. Irvine, A.M. Mayes, L.G. Griffith, Biomacromolecules 2, 85 (2001)
• 13. S. Jo, P.S. Engel, A. G.Mikos, Polymer 41, 7595 (2000)
• 14. S.Lj. Tomić, E.H. Suljovrujić, J.M. Filipović, Polym. Bull57, 691 (2006)
• 15. S.Lj. Tomić, M.M. Mićić, J.M. Filipović, E.H. Suljovrujić, Radiat. Phys. Chem. 76, 801 (2007)
• 16. S.Lj. Tomić, M.M. Mićić, S.N. Dobić, J.M. Filipović, E.H. Suljovrujić, Radiat. Phys. Chem. 79, 643 (2010)
• 17. S.Lj. Tomić, M.M. Mićić, J.M. Filipović, E.H. Suljovrujić, Chem. Eng. J160, 801 (2010)
• 18. C.L. Bell, N.A. Peppas, J. Control. Release 37, 277 (1995)
• 19. N.A. Peppas, Pharm. Acta Helv. 60, 110 (1985)
• 20. B.D. Johnson, D.J. Niedermaier, W.C. Crone, J. Moorthy, D.J. Beebe, Mechanical Properties of a pH Sensitive Hydrogel, Session on Biologically Inspire Synthesis and Properties, Proceedings of the SEM Annual Conference on Experimental Mechanics (Milwaukee, WI, 2002)
• 21. G. D'Errico, M. De Lellis, G. Mangiapia, A. Tedeschi, O. Ortona, S. Fusco, A. Borzacchiello, L. Ambrosio, Biomacromolecules 9, 231 (2008)
• 22. H. Yu, X. Xu, X. Chen, T. Lu, P. Zhang, X. Jing, J. Appl. Polym. Sci103, 125 (2006)
• 23. Antimicrobial/Anti-Infective Materials: Principles and Applications, Eds. S.P. Sawan, G. Manivannan, CRC Press, USA, 1999
• 24. L. Martineau, P.N. Shek, Burns 32, 172 (2006)
• 25. P.J. Houghton, P.J. Hylands, A.Y. Mensah, A. Hensel, A.M. Deters, J. Ethnopharmacol. 100, 100 (2005)

Identifiers

DOI

10.12693/APhysPolA.120.279