Mechanochemical Preparation of Organic-Inorganic Hybrid Materials of Drugs with Inorganic Oxides

• Authors: T. Shakhtshneider , S. Myz , M. Dyakonova , V. Boldyrev , E. Boldyreva , A. Nizovskii , A. Kalinkin , Rakesh Kumar
• Languages of publication: EN

Abstracts

EN

The nanocomposites of piroxicam and meloxicam with alumina were obtained by ball-milling as a result of distribution of the drugs at the surface of oxide with formation of the stable composites. The observed changes in the IR spectra of the ball-milled mixtures suggested the interaction of the drugs with the alumina active surface sites. The functional groups in molecules of piroxicam and meloxicam involved into formation of bonds between the drugs and the surface of the oxide were determined, they are amide, sulfate, enol groups, and pyridyl / thiazolyl nitrogen atoms. It appears that the formation of the new bonds at the contacts of particles in the composite leads to the stabilization of the drugs in metastable state inhibiting their transformation into initial crystalline form.

Keywords

EN

62.25.-g

Discipline

• 62.25.-g: Mechanical properties of nanoscale systems(for structure of nanoscale systems, see 61.46.-w; for structural transitions in nanoscale materials, see 64.70.Nd; for electronic transport in nanoscale systems, see 73.63.-b)

• Journal: Acta Physica Polonica A
• Year: 2011
• Volume: 120
• Issue: 2
• Pages: 272-278

Dates

published

2011-08

Contributors

author

T. Shakhtshneider

• Institute of Solid State Chemistry and Mechanochemistry, Kutateladze str., 18, Novosibirsk, 630128, Russia
• Research and Education Center "Molecular Design and Ecologically Safe Technologies" at Novosibirsk State University, Pirogova str., 2, Novosibirsk, 630090, Russia

author

S. Myz

• Institute of Solid State Chemistry and Mechanochemistry, Kutateladze str., 18, Novosibirsk, 630128, Russia
• Research and Education Center "Molecular Design and Ecologically Safe Technologies" at Novosibirsk State University, Pirogova str., 2, Novosibirsk, 630090, Russia

author

M. Dyakonova

• Institute of Solid State Chemistry and Mechanochemistry, Kutateladze str., 18, Novosibirsk, 630128, Russia
• Research and Education Center "Molecular Design and Ecologically Safe Technologies" at Novosibirsk State University, Pirogova str., 2, Novosibirsk, 630090, Russia

author

V. Boldyrev

• Institute of Solid State Chemistry and Mechanochemistry, Kutateladze str., 18, Novosibirsk, 630128, Russia
• Research and Education Center "Molecular Design and Ecologically Safe Technologies" at Novosibirsk State University, Pirogova str., 2, Novosibirsk, 630090, Russia

author

E. Boldyreva

• Institute of Solid State Chemistry and Mechanochemistry, Kutateladze str., 18, Novosibirsk, 630128, Russia
• Research and Education Center "Molecular Design and Ecologically Safe Technologies" at Novosibirsk State University, Pirogova str., 2, Novosibirsk, 630090, Russia

author

A. Nizovskii

• Boreskov Institute of Catalysis, pr. Lavrentieva, 5, Novosibirsk, 630090, Russia

author

A. Kalinkin

• Boreskov Institute of Catalysis, pr. Lavrentieva, 5, Novosibirsk, 630090, Russia

author

Rakesh Kumar

• National Metallurgical Laboratory, Jamshedpur-831 007, India

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Identifiers

DOI

10.12693/APhysPolA.120.272