Thermal Analysis of Magnetic Polymer Nanospheres for Drug Targeting

• Authors: A. Juríková , K. Csach , J. Miškuf , M. Koneracká , V. Závišová , P. Kopčanský
• Languages of publication: EN

Abstracts

EN

Poly(D,L-lactic-co-glycolic) acid (PLGA) polymer nanospheres loaded with different input amounts of anticancer drug taxol were prepared by the modified nanoprecipitation method. Magnetite was incorporated into the polymer nanospheres to impart them superparamagnetic properties. Thermal properties of the drug loaded magnetic polymer nanospheres were characterized using differential scanning calorimetry and thermogravimetric analysis. The solid state solubility of taxol in PLGA nanospheres and the influence of external magnetic field on their thermal stability were estimated. The investigations have revealed that the samples of dried taxol loaded magnetic PLGA nanospheres undergo mass loss at three stages during heating.

Keywords

EN

47.65.Cb; 65.80.-g; 47.63.mh

Discipline

• 47.65.Cb: Magnetic fluids and ferrofluids
• 47.63.mh: Transport processes and drug delivery
• 65.80.-g: Thermal properties of small particles, nanocrystals, nanotubes, and other related systems

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2010
• Volume: 118
• Issue: 5
• Pages: 990-992

Dates

published

2010-11

Contributors

author

A. Juríková

• Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia

author

K. Csach

• Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia

author

J. Miškuf

• Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia

author

M. Koneracká

• Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia

author

V. Závišová

• Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia

author

P. Kopčanský

• Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia

References

• 1. Q.A. Pankhurst, J. Connolly, S.K. Jones, J. Dobson, J. Phys. D, Appl. Phys. 36, R167 (2003)
• 2. J. Panyam, D. Williams, A. Dash, D. Leslie-Pelecky, V. Labhasetwar, J. Pharm. Sci. 93, 1804 (2004)
• 3. C. Dubernet, Thermochim. Acta 248, 259 (1994)
• 4. M. Koneracká, M. Múčková, V. Závišová, N. Tomašovičová, P. Kopčanský, M. Timko, A. Juríková, K. Csach, V. Kavečanský, G. Lancz, J. Phys., Condens. Matter 20, 204151 (2008)

Identifiers

DOI

10.12693/APhysPolA.118.990