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2010 | 118 | 5 | 983-985
Article title

Characterization of Fe_3O_4 Magnetic Nanoparticles Modified with Dextran and Investigation of Their Interaction with Protein Amyloid Aggregates

Content
Title variants
Languages of publication
EN
Abstracts
EN
Functionalised magnetic nanoparticles composed of Fe_3O_4 particles stabilised by sodium oleate and subsequently modified with dextran (MFDEX) were prepared by the co-precipitation method. Their morphology and particle size distribution were observed by scanning electron microscopy and photon cross correlation spectroscopy. In order to confirm the modification of magnetite surface with dextran physical techniques, including infrared spectroscopy, thermal analysis, and magnetic measurement, were used. Finally, the effect of MFDEX on amyloid fibrillar aggregates of human insulin and hen egg white lysozyme, typical amyloidogenic proteins, was investigated. In vitro interaction of MFDEX with protein amyloid fibrils resulted into destruction of amyloid aggregates. The anti-amyloid activity makes MFDEX of potential interest as therapeutic agent against amyloid-related diseases.
Keywords
EN
Year
Volume
118
Issue
5
Pages
983-985
Physical description
Dates
published
2010-11
References
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  • 2. J.D. Sipe, Amyloid Proteins, Wiley-VCH, Weinheim 2005 and references inside
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  • 8. S.S.-S. Wang, K.-N. Liu, W.-H. Lee, Biophys. Chem. 144, 78 (2009)
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-appv118n5110kz
Identifiers
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