An Ellipsometrical and AFM Study οf Ferritin Adsorption Kinetics on a Gold Surface

• Authors: L. Vladimirova , A. Andreeva , V. Savov , A. Gritzkow , M. Burova
• Languages of publication: EN

Abstracts

EN

The kinetics of ferritin adsorption on gold (Au) surface was studied with ellipsometry and atomic force microscopy. The thickness and the refraction index of the adsorbed layer were determined using a theoretical model system: air-interface layer-solution-adsorbed layer-gold surface. The relations between the parameters of the adsorbed layer and pH and the protein concentration are obtained. It seems that the ferritin adsorption is a relatively slow multi-stage process. The obtained results enable modelling of the protein adsorption on blood vessels and tissues in pathological processes. The kinetics of protein adsorption could be implemented in medical applications and in development of new biosensor systems.

Keywords

EN

79.60.Dp; 42.62.Be; 73.30.+y; 78.68.+m

Discipline

• 79.60.Dp: Adsorbed layers and thin films
• 78.68.+m: Optical properties of surfaces
• 73.30.+y: Surface double layers, Schottky barriers, and work functions(see also 82.45.Mp Thin layers, films, monolayers, membranes in electrochemistry; see also 87.16.D- Membranes, bilayers, and vesicles in biological physics)
• 42.62.Be: Biological and medical applications(see also 87.50.W-, 87.63.L-, and 87.80.Cc in biological and medical physics)

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2009
• Volume: 116
• Issue: 4
• Pages: 687-689

Dates

published

2009-10

Contributors

author

L. Vladimirova

• Faculty of Physics, Department of Atomic Physics, Sofia University "St. Kliment Ohridski", 5 James Boucher Blvd., 1164 Sofia, Bulgaria

author

A. Andreeva

• Faculty of Physics, Department of Semiconductors, Sofia University "St. Kliment Ohridski", 5 James Boucher Blvd., 1164 Sofia, Bulgaria

author

V. Savov

• Faculty of Physics, Department of Atomic Physics, Sofia University "St. Kliment Ohridski", 5 James Boucher Blvd., 1164 Sofia, Bulgaria

author

A. Gritzkow

• Faculty of Physics, Department of Optics, Sofia University "St. Kliment Ohridski", 5 James Boucher Blvd., 1164 Sofia, Bulgaria

author

M. Burova

• Faculty of Physics, Department of Semiconductors, Sofia University "St. Kliment Ohridski", 5 James Boucher Blvd., 1164 Sofia, Bulgaria

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Identifiers

DOI

10.12693/APhysPolA.116.687