High-Voltage Pulses Potentiate Bleomycin Cytotoxicity Towards Cancer Cells in vitro

• Authors: R. Saulė , G. Saulis , D. Batiuškaitė
• Languages of publication: EN

Abstracts

EN

In this study the influence of high-voltage pulses on bleomycin cytotoxicity towards mouse hepatoma MH-22A and rat glioma C6 cells in vitro was determined. It was obtained that combining bleomycin with pulses of strong electric field significantly enhances the number of cells killed by bleomycin. Bleomycin alone was cytotoxic to both cell lines at concentrations above 1 μM. Treatment of cells by electric pulses in the presence of bleomycin greatly potentiated its cytotoxicity towards both cell lines tested - the bleomycin concentration required to reduce cell survival by 50% was 3.5-3.8 nM only. Exposure of cells to electric pulses only did not reduce cell viability.

Keywords

EN

87.50.cj; 87.80.Fe; 87.50.cf

Discipline

• 87.50.cf: Biophysical mechanisms of interaction
• 87.50.cj: Electroporation/membrane effects
• 87.80.Fe: Micromanipulation of biological structures

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2009
• Volume: 115
• Issue: 6
• Pages: 1098-1100

Dates

published

2009-06

Contributors

author

R. Saulė

• Vytautas Magnus University, 58 K. Donelaičio str., Kaunas, Lithuania

author

G. Saulis

• Vytautas Magnus University, 58 K. Donelaičio str., Kaunas, Lithuania

author

D. Batiuškaitė

• Vytautas Magnus University, 58 K. Donelaičio str., Kaunas, Lithuania

References

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Identifiers

DOI

10.12693/APhysPolA.115.1098