Application of μ-FTIR-SR Spectroscopy to Prostate Tissue Analysis

• Authors: W. Kwiatek , C. Paluszkiewicz , A. Banaś , A. Kisiel , M. Podgórczyk , A. Marcelli , M. Cestelli Guidi , M. Piccinini
• Languages of publication: EN

Abstracts

EN

The infrared spectromicroscopy is a quite recent technique rapidly developing thanks to the availability of new instruments and new brilliant synchrotron radiation sources in different areas and in particular to biomedical researches. In order to achieve a diffraction limited spatial resolution in tissue samples, we performed experiments at SINBAD, the synchrotron infrared beamline of the Laboratori Nazionali di Frascati. We characterized the chemical composition of prostate tissue samples taken from patients affected by prostate cancer disease. Different sizes of the pinholes were considered for the measurements. In the case of prostate tissue sections the results show the possibility to determine the intensity ratio of the CH_2 and CH_3 bands set at 2930 cm^{-1} and 2960 cm^{-1}, respectively. Experiments were also performed with a pinhole of 5 μm of diameter and the differences in both histological and chemical compositions of such samples were determined.

Keywords

EN

87.64.km; 87.64.kp; 87.64.Ee; 87.85.jf

Discipline

• 87.64.Ee: Electron microscopy
• 87.64.km: Infrared
• 87.85.jf: Bio-based materials
• 87.64.kp: Raman

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2009
• Volume: 115
• Issue: 2
• Pages: 602-605

Dates

published

2009-02

Contributors

author

W. Kwiatek

• Institute of Nuclear Physics, PAS, Radzikowskiego 152, 31-342 Kraków, Poland

author

C. Paluszkiewicz

• AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Kraków, Poland

author

A. Banaś

• Institute of Nuclear Physics, PAS, Radzikowskiego 152, 31-342 Kraków, Poland

author

A. Kisiel

• Institute of Physics, Jagiellonian University, Reymonta 4, 30-059 Kraków, Poland

author

M. Podgórczyk

• Institute of Nuclear Physics, PAS, Radzikowskiego 152, 31-342 Kraków, Poland

author

A. Marcelli

• INFN - Laboratori Nazionali di Frascati, Via E. Fermi 40, I-00044 Frascati (Rome), Italy

author

M. Cestelli Guidi

• INFN - Laboratori Nazionali di Frascati, Via E. Fermi 40, I-00044 Frascati (Rome), Italy
• Universita' Roma Tre, Dip. Scienze Geologiche, L. go S. Leonardo Murialdo 1, 00146 Rome, Italy

author

M. Piccinini

• INFN - Laboratori Nazionali di Frascati, Via E. Fermi 40, I-00044 Frascati (Rome), Italy
• Universita' Roma Tre, Dip. Scienze Geologiche, L. go S. Leonardo Murialdo 1, 00146 Rome, Italy

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Identifiers

DOI

10.12693/APhysPolA.115.602