Challenges in Biology and Medicine with Synchrotron Infrared Light

• Authors: P. Dumas , L. Miller , M. Tobin
• Languages of publication: EN

Abstracts

EN

The brightness (or brilliance) of synchrotron radiation was exploited in infrared microspectrosocopy. Among application of this synchrotron-based microanalytical technique, biological and biomedical investigations, at the diffraction-limited spot size, are exhibit of an increasing interest among almost all the existing infrared beamline worldwide. This paper is presenting the main properties of such a source, coupled with an infrared microscope. Several important applications in biomedical field are reported: cancer cells studies and drug effects, human substantia nigra in Parkinson's disease, β-amyloids deposits in Alzheimer's disease.

Keywords

EN

87.80.Dj; 87.80.-y; 87.64.km; 87.56.B-; 87.19.xj; 87.16.-b; 87.15.bd; 78.30.-j

Discipline

• 87.15.bd: Secondary structure
• 87.56.B-: Radiation sources
• 87.64.km: Infrared
• 87.16.-b: Subcellular structure and processes
• 87.19.xj: Cancer
• 78.30.-j: Infrared and Raman spectra(for vibrational states in crystals and disordered systems, see 63.20.-e and 63.50.-x, respectively; for Raman spectra of superconductors, see 74.25.nd)
• 87.80.-y: Biophysical techniques (research methods)
• 87.80.Dj: Spectroscopies

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2009
• Volume: 115
• Issue: 2
• Pages: 446-454

Dates

published

2009-02

Contributors

author

P. Dumas

• SOLEIL Synchrotron, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette Cedex, France

author

L. Miller

• National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA

author

M. Tobin

• Australian Synchrotron Project, 800 Blackburn Road, Clayton Victoria, Australia

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Identifiers

DOI

10.12693/APhysPolA.115.446