Sulphur XANES Analysis of Cultured Human Prostate Cancer Cells

• Authors: W. Kwiatek , M. Podgórczyk , Cz. Paluszkiewicz , A. Balerna , A. Kisiel
• Languages of publication: EN

Abstracts

EN

Prostate cancer is one of the most commonly diagnosed cancers in men throughout the world. It is believed that changes to the structure of protein binding sites, altering its metabolism, may play an important role in carcinogenesis. Sulphur, often present in binding sites, can influence such changes through its chemical speciation. Hence there is a need for precise investigation of coordination environment of sulphur. X-ray absorption near edge structure spectroscopy offers such possibility. Cell culture samples offer histologically well defined areas of good homogeneity, suitable for successful and reliable X-ray absorption near edge structure analysis. This paper presents sulphur speciation data collected from three different human prostate cancer cell lines (PC-3, LNCaP and DU-145). Sulphur X-ray absorption near edge structure analysis was performed on K-edge structure. The spectra of cells were compared with those of cancerous tissue and with organic substances as well as inorganic compounds.

Keywords

EN

87.64.kd; 87.19.xj

Discipline

• 87.19.xj: Cancer
• 87.64.kd: X-ray and EXAFS

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2008
• Volume: 114
• Issue: 2
• Pages: 463-470

Dates

published

2008-08

received

2007-09-24

Contributors

author

W. Kwiatek

• The Henryk Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow Poland

author

M. Podgórczyk

• The Henryk Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow Poland

author

Cz. Paluszkiewicz

• AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Cracow, Poland

author

A. Balerna

• INFN - Laboratori Nazionali di Frascati, Via E. Fermi 40, I-00044 Frascati, Italy

author

A. Kisiel

• Institute of Physics, Jagiellonian University, Reymonta 4, 30-059 Cracow, Poland

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Identifiers

DOI

10.12693/APhysPolA.114.463