Development of Low-Cost Photodynamic Therapy Device

• Authors: N. Momchilov , I. Bliznakova , E. Borisova , P. Troyanova , L. Avramov
• Languages of publication: EN

Abstracts

EN

Photodiagnosis and photodynamic therapy of non-melanoma skin cancers using delta-aminolevulinic acid/protoporphyrin IX (5-ALA/PpIX) give a combined application with broadest dissemination in the current clinical practice. The problems with using of lasers as light sources are the expenses associated with the operation of these types of installations. This is why we test the capability of cheaper sources - light-emitting diodes at 405 nm for fluorescence excitation of PpIX and 635 nm for photodynamic action initiation. A LED matrix is developed in our laboratory using two types of LEDs and a combined photodiagnosis/photodynamic theory device applicable for clinical practice is built. Geometrically matrix is formed in such way that power density at 635 nm is about 40 mW/cm^2, which allow to reach treatment doses for a 15-20 min irradiation depending of the lesion size in the focus of the system. The therapeutic mode of system developed can be used also with some other photosensitizers from the porphyrins derivatives family.

Keywords

EN

42.72.Bj; 87.64.kv; 87.19.xj

Discipline

• 87.19.xj: Cancer
• 87.64.kv: Fluorescence
• 42.72.Bj: Visible and ultraviolet sources

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2007
• Volume: 112
• Issue: 5
• Pages: 1125-1130

Dates

published

2007-11

received

2007-09-03

Contributors

author

N. Momchilov

• Institute of Electronics, Bulgarian Academy of Sciences, Sofia, Bulgaria

author

I. Bliznakova

• Institute of Electronics, Bulgarian Academy of Sciences, Sofia, Bulgaria

author

E. Borisova

• Institute of Electronics, Bulgarian Academy of Sciences, Sofia, Bulgaria

author

P. Troyanova

• National Oncological Center, Sofia, Bulgaria

author

L. Avramov

• Institute of Electronics, Bulgarian Academy of Sciences, Sofia, Bulgaria

References

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• 4. A. Katzir, Lasers and Optical Fibers in Medicine, Academic Press, San Diego (CA) 1993
• 5. E. Borisova, B. Vladimirov, I. Angelov, L. Avramov, Proc. SPIE, 6604, 6604-2H, 2007
• 6. F. Fischer, E. Dickson, J. Kennedy, R. Pottier, Lasers Med. Sci., 16, 207, 2001
• 7. M. Ericson, J. Uhre, C. Strandeberg, B. Stenquist, O. Larko, A. Wennberg, A. Rosen, J. Biomed. Opt., 10, 034009, 2005
• 8. http://www.biospec.ru/

Identifiers

DOI

10.12693/APhysPolA.112.1125