PL EN


Preferences help
enabled [disable] Abstract
Number of results
2006 | 110 | 5 | 631-640
Article title

Hydrolytic Degradation of Poly(L-Lactide-co-Glycolide) Studied by Positron Annihilation Lifetime Spectroscopy and Other Techniques

Content
Title variants
Languages of publication
EN
Abstracts
EN
Changes of the poly(L-lactide-co-glycolide) structure as a function of degradation time in phosphate-buffered saline for 7 weeks were investigated by gel permeation chromatography, differential scanning calorimetry, nuclear magnetic resonance (^1H NMR), and positron annihilation lifetime spectroscopy. Surface properties as wettability by sessile drop and topography by atomic force microscopy were also characterized. Chain-scission of polyester bonds in hydrolysis reaction causes a quite uniform decrease in molecular weight, and finally results in an increase in semicrystallinity. Molecular composition of the copolymer and water contact angle do not change considerably during degradation time. Atomic force microscopy studies suggest that the copolymer degrades by "in bulk" mechanism. The average size of the molecular-level free volume holes declines considerably after one week of degradation and remains constant till the sixth week of degradation. The free volume fraction decreases as a function of degradation time.
Keywords
Contributors
author
  • Faculty of Materials Science and Ceramics, Department of Biomaterials, AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Kraków, Poland
author
  • Institute of Nuclear Physics, Radzikowskiego 152, 31-342 Kraków, Poland
  • Centre of Polymer Chemistry, Polish Academy of Sciences, Curie-Skłodowskiej 34/20, 41-819 Zabrze, Poland
References
  • 1. R. Chandra, R. Rustgi, Prog. Polym. Sci., 23, 1273, 1998
  • 2. S.-J. Sieh, J.P. Vacanti, Surgery, 257, 1, 2005
  • 3. B.L. Seal, T.C. Otero, A. Panitch, Mater. Sci. Eng. R, 34, 147, 2001
  • 4. I. Grizzi, H. Garreau, S. Li, M. Vert, Biomaterials, 16, 305, 1995
  • 5. S. Li, S. McCarthy, Biomaterials, 20, 35, 1999
  • 6. X. Yuan, A.F.T. Mak, K. Yao, Polym. Degrad. Stab., 75, 45, 2002
  • 7. E. Pamula, P. Dobrzyski, M. Bero, C. Paluszkiewicz, J. Mol. Struct., 744-747, 557, 2005
  • 8. Y.C. Jean, Microchem. J., 42, 72, 1990
  • 9. Y.Y. Wang, H. Nakanishi, J.C. Jean, T.C. Sandreczki, J. Polym. Sci. Polym. Phys., 28, 1431, 1990
  • 10. Y. Kobayashi, S. Haraya, S. Hattori, T. Sasuga, Polymer, 35, 927, 1994
  • 11. A.J. Hill, S. Weinhold, G.M. Stack, M.R. Tant, Eur. Polym. J., 32, 843, 1996
  • 12. Z.F. Wang, B. Wang, X.M. Ding, M. Zhang, L.M. Liu, N. Qi, J.L. Hu, J. Membr. Sci., 241, 355, 2004
  • 13. E.-A. McGonigle, J.J. Liggat, R.A. Pethrick, S.D. Jenkins, J.H. Daly, D. Hayward, Polymer, 42, 2413, 2001
  • 14. M. Misheva, N. Djourelov, E.T. Netkov, Radiation Phys. Chem., 62, 379, 2001
  • 15. P. Golonka, J. Mayer, E. Dryzek, Acta Phys. Pol. A, 99, 363, 2001
  • 16. L. Brambilla, G. Consolati, R. Gallo, F. Quasso, F. Severini, Polymer, 44, 1041, 2003
  • 17. P. Dobrzyński, J. Kasperczyk, H. Janeczek, M. Bero, Macromolecules, 34, 5090, 2001
  • 18. O.F. Solomon, I.Z. Ciuta, J. Appl. Polym. Sci., 6, 683, 1962
  • 19. J. Kansy, Nucl. Instrum. Methods Phys. Res. A, 374, 235, 1996
  • 20. S.J. Tao, J. Chem. Phys., 56, 5491, 1972
  • 21. M. Eldrup, D. Lightbody, J.N. Sherwood, Chem. Phys., 63, 51, 1981
  • 22. A. Ballara, J. Verdu, Polym. Degrad. Stab., 26, 361, 1989
  • 23. N. Iliskovic, M. Bravar, Polym. Degrad. Stab., 15, 173, 1986
  • 24. A. Buttafava, G. Consolati, L. Di Landro, M. Mariani, Polymer, 43, 7477, 2002
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv110n510kz
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.