PL EN


Preferences help
enabled [disable] Abstract
Number of results
2006 | 109 | 3 | 329-334
Article title

The GSI Heavy Ion Microbeam: A Tool for the Investigation of Cellular Response to High LET Radiations

Content
Title variants
Languages of publication
EN
Abstracts
EN
Since the mid 1990's, an increasing number of charged particle microbeams have been designed to deliver a preset number of ions to individual living cells with the micron resolution. These tools provide a powerful technique to investigate the cellular response to low doses of radiations. During the last years, the single ion hit facility in operation on the GSI microbeam since 1987 has been upgraded for the irradiation of individual living cells in vitro. This setup presents two main peculiarities compared to the microbeams used up to now for cell irradiation. First, the beam's micrometric size is obtained by magnetic focusing and not by a simple collimation. This allows obtaining a smaller beam spot, a better defined linear energy transfer, and a high irradiation throughput. Then, the GSI microbeam is able to focus ions from carbon to uranium with energies between 1.4 MeV/u to 11.4 MeV/u. The range of accessible linear energy transfer is thus considerably extended compared to light ions microbeam in operation today. The design of the GSI microbeam is described, including the beam control, the online cell localisation, the cell dish designed specifically for microbeam irradiation, and the cell irradiation procedures. Experimental tests performed to check the global aiming accuracy as well as the first cellular irradiations are presented.
Keywords
EN
Publisher

Year
Volume
109
Issue
3
Pages
329-334
Physical description
Dates
published
2006-03
received
2005-05-20
Contributors
author
  • Materials Research, GSI, Planckstr. 1, 64291 Darmstadt, Germany
author
  • Materials Research, GS, Planckstr. 1, 64291 Darmstadt, Germany
  • CENBG, B.P. 120, 33175 Gradignan cedex, France
author
  • Materials Research, GSI, Planckstr. 1, 64291 Darmstadt, Germany
author
  • Materials Research, GSI, Planckstr. 1, 64291 Darmstadt, Germany
  • Biophysics, GSI, Planckstr. 1, 64291 Darmstadt, Germany
References
  • 1. M. Folkard, B. Vojnovic, K.M. Prise, B.D. Michael, Nucl. Instrum. Methods Phys. Res. B, 188, 49, 2002
  • 2. C. Mothersill, C. Seymour, Mutation Research, 568, 121, 2004
  • 3. K.M. Prise, O.V. Belyakov, M. Folkard, A. Ozols, G. Schettino, B. Vojnovic, B.D. Michael, Adv. Space Res., 30, 871, 2002
  • 4. M. Folkard, B. Vojnovic, K.M. Prise, A.G. Bowey, R.J. Locke, G. Schettino, B.D. Michael, Int. J. Radiat. Biol., 72, 375, 1997
  • 5. G. Randers-Pehrson, C.R. Geard, G. Johnson, C.D. Elliston, D.J. Brenner, Radiat. Res., 156, 210, 2001
  • 6. K.D. Greif, H.J. Brede, D. Frankenberg, U. Giesen, Nucl. Instrum. Methods Phys. Res. B, 217, 505, 2004
  • 7. A. Hauptner, S. Dietzel, G.A. Drexler, P. Reichart, R. Krücken, T. Cremer, A.A. Friedl, G. Dollinger, Radiat. Environ. Biophys., 42, 237, 2004
  • 8. Ph. Barberet, A. Balana, S. Incerti, C. Michelet-Habchi, Ph. Moretto, Th. Pouthier, Rev. Sci. Instrum., 76, 015101, 2005
  • 9. B.E. Fischer, Nucl. Instrum. Methods Phys. Res. B, 30, 284, 1988
  • 10. B.E. Fischer, Nucl. Instrum. Methods Phys. Res. B, 10-11, 693, 1985
  • 11. B. Jakob, M. Scholz, G. Taucher-Scholz, Radiat. Res., 159, 676, 2003
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv109n311kz
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.