PL EN


Preferences help
enabled [disable] Abstract
Number of results
2006 | 109 | 3 | 265-271
Article title

Investigating Mechanisms of Radiation-Induced DNA Damage Using Low-Energy Photons

Authors
Content
Title variants
Languages of publication
EN
Abstracts
EN
Central to any mechanistic biophysical model of radiation damage to DNA is the relationship between the amount and distribution of energy deposited in the DNA helix and the subsequent production of DNA damage. It is now clear from a number of studies that the minimum energy required to produce bond breaks in DNA is significantly lower than might be expected. For example, some biophysical models have assumed that it takes several 10s of eV to produce a double-strand break in DNA. However, using low-energy photons, we have shown that energy depositions as low as 7 eV can induce double-strand break and that this is enhanced when the DNA is hydrated, showing that free radical damage is also important.
Keywords
EN
Publisher

Year
Volume
109
Issue
3
Pages
265-271
Physical description
Dates
published
2006-03
received
2005-05-20
Contributors
author
  • Gray Cancer Institute, Mount Vernon Hospital, P.O. Box 100, Northwood, HA6 2JR, UK
author
  • Gray Cancer Institute, Mount Vernon Hospital, P.O. Box 100, Northwood, HA6 2JR, UK
References
  • 1. H. Nikjoo, P. O'Neill, M. Terrissol, D.T. Goodhead, Int. J. Radiat. Biol., 66, 453, 1994
  • 2. H. Nikjoo, P. O'Neill, D.T. Goodhead, M. Terrissol, Int. J. Radiat. Biol., 71, 467, 1997
  • 3. B. Boudaiffa, P. Cloutier, D. Hunting, M.A. Huels, L. Sanche, Science, 287, 1658, 2000
  • 4. F. Martin, P.D. Burrow, Z. Cai, P. Cloutier, D. Hunting, L. Sanche, Phys. Rev. Lett., 1993, 068101, 2004
  • 5. K.M. Prise, M. Folkard, B.D. Michael, B. Vojnovic, B. Brocklehurst, A. Hopkirk, I.H. Munro, Int. J. Radiat. Biol., 76, 881, 2000
  • 6. M. Folkard, K.M. Prise, B. Vojnovic, B. Brocklehurst, B.D. Michael, Int. J. Radiat. Biol., 76, 763, 2000
  • 7. M. Folkard, K.M. Prise, C.J. Turner, B.D. Michael, Radiat. Prot. Dosimetry, 1999, 147, 2002
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv109n304kz
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.