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2005 | 108 | 2 | 353-356
Article title

Paramagnetic Centers in DOPA-Melanin-Dihydrostreptomycin Complexes

Content
Title variants
Languages of publication
EN
Abstracts
EN
DOPA-melanin-dihydrostreptomycin complexes with drug concentrations 1×10^{-4}-1×10^{-2} M were examined by the use of electron paramagnetic resonance spectroscopy at X-band (9.3 GHz). Dihydrostreptomycin was chosen for studies, because this aminoglycoside antibiotic causes strong toxic effects in organism. It was stated that dihydrostreptomycin generates o-semiquinone free radicals with g=2.0038 in melanin. Free radicals formation increases with increase in the antibiotic concentration. Changes of EPR lines with microwave powers pointed out that slow spin-lattice relaxation processes exist in DOPA-melanin and in its complexes with dihydrostreptomycin. The measured EPR lines were homogeneously broadened.
Keywords
EN
Publisher

Year
Volume
108
Issue
2
Pages
353-356
Physical description
Dates
published
2005-08
received
2005-04-24
Contributors
author
  • Department of Pharmaceutical Chemistry, School of Pharmacy, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland
author
  • Department of Medical Physics, School of Pharmacy, Medical University of Silesia, Narcyzów 1, 41-200 Sosnowiec, Poland
author
  • Department of Medical Physics, School of Pharmacy, Medical University of Silesia, Narcyzów 1, 41-200 Sosnowiec, Poland
author
  • Department of Pharmaceutical Chemistry, School of Pharmacy, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland
  • Department of Pharmaceutical Chemistry, School of Pharmacy, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland
author
  • Department of Molecular Biology and Medical Genetics, School of Pharmacy, Medical University of Silesia, Narcyzów 1, 41-200 Sosnowiec, Poland
References
  • 1. E. Buszman, B. Pilawa, T. Witoszyńska, M. Latocha, T. Wilczok, Appl. Magn. Res., 24, 401, 2003
  • 2. B. Pilawa, E. Buszman, D. Wrześniok, M. Latocha, T. Wilczok, Appl. Magn. Res., 23, 181, 2002
  • 3. B. Pilawa, M. Latocha, E. Buszman, T. Wilczok, Appl. Magn. Res., 25, 105, 2003
  • 4. E. Buszman, B. Pilawa, M. Zdybel, D. Wrześniok, A. Grzegorczyk, T. Wilczok, Chem. Phys. Lett., 403, 22, 2005
  • 5. J.G. Hardman, L.E. Limbird, P.B. Molinoff, R.W. Ruddon, G.A. Gilman, The Pharmacological Basis of Therapeutics, McGraw-Hill, 1996
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-appv108n217kz
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