Paramagnetic Centers in DOPA-Melanin-Dihydrostreptomycin Complexes

• Authors: E. Buszman , B. Pilawa , M. Zdybel , D. Wrześniok , A. Grzegorczyk , T. Wilczok
• Languages of publication: EN

Abstracts

EN

DOPA-melanin-dihydrostreptomycin complexes with drug concentrations 1×10^{-4}-1×10^{-2} M were examined by the use of electron paramagnetic resonance spectroscopy at X-band (9.3 GHz). Dihydrostreptomycin was chosen for studies, because this aminoglycoside antibiotic causes strong toxic effects in organism. It was stated that dihydrostreptomycin generates o-semiquinone free radicals with g=2.0038 in melanin. Free radicals formation increases with increase in the antibiotic concentration. Changes of EPR lines with microwave powers pointed out that slow spin-lattice relaxation processes exist in DOPA-melanin and in its complexes with dihydrostreptomycin. The measured EPR lines were homogeneously broadened.

Keywords

EN

61.66.Hq; 76.30.Rn

Discipline

• 76.30.Rn: Free radicals
• 61.66.Hq: Organic compounds

• Journal: Acta Physica Polonica A
• Year: 2005
• Volume: 108
• Issue: 2
• Pages: 353-356

Dates

published

2005-08

received

2005-04-24

Contributors

author

E. Buszman

• Department of Pharmaceutical Chemistry, School of Pharmacy, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland

author

B. Pilawa

• Department of Medical Physics, School of Pharmacy, Medical University of Silesia, Narcyzów 1, 41-200 Sosnowiec, Poland

author

M. Zdybel

• Department of Medical Physics, School of Pharmacy, Medical University of Silesia, Narcyzów 1, 41-200 Sosnowiec, Poland

author

D. Wrześniok

• Department of Pharmaceutical Chemistry, School of Pharmacy, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland

author

A. Grzegorczyk

• Department of Pharmaceutical Chemistry, School of Pharmacy, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland

author

T. Wilczok

• Department of Molecular Biology and Medical Genetics, School of Pharmacy, Medical University of Silesia, Narcyzów 1, 41-200 Sosnowiec, Poland

References

• 1. E. Buszman, B. Pilawa, T. Witoszyńska, M. Latocha, T. Wilczok, Appl. Magn. Res., 24, 401, 2003
• 2. B. Pilawa, E. Buszman, D. Wrześniok, M. Latocha, T. Wilczok, Appl. Magn. Res., 23, 181, 2002
• 3. B. Pilawa, M. Latocha, E. Buszman, T. Wilczok, Appl. Magn. Res., 25, 105, 2003
• 4. E. Buszman, B. Pilawa, M. Zdybel, D. Wrześniok, A. Grzegorczyk, T. Wilczok, Chem. Phys. Lett., 403, 22, 2005
• 5. J.G. Hardman, L.E. Limbird, P.B. Molinoff, R.W. Ruddon, G.A. Gilman, The Pharmacological Basis of Therapeutics, McGraw-Hill, 1996

Identifiers

DOI

10.12693/APhysPolA.108.353