Hydration of Hydroxypropylmethyl Cellulose: Effects of pH and Molecular Mass

• Authors: J. Tritt-Goc , J. Kowalczuk , N. Piślewski
• Languages of publication: EN

Abstracts

EN

Magnetic resonance imaging was used to study the diffusion of a water solution of hydrochloric acid (HCl) and sodium hydrochloride (NaOH) into hydroxypropylmethyl cellulose matrices. Polymer in the form of a cylinder was hydrated in a water solvent of pH = 2, 7, and 12 at 37ºC and monitored at equal intervals with a 300 MHz Bruker AVANCE. The spatially resolved spin-spin relaxations times and spin densities, along with a change in the dimension of the glass core of the polymer were determined for hydroxypropylmethyl cellulose tablets as a function of hydration times. The data showed the effects of the pH solvent and of the molecular mass of the polymer on the swelling process, spin-spin relaxation time, and diffusion of solvent molecules into hydroxypropylmethyl cellulose matrices. The time dependence of the diffusion front, effective T_2, and proton-density ρ analysis clearly indicate a case II diffusion mechanism in the system composed of a water solution of hydrochloric acid (pH = 2) and hydroxypropylmethyl cellulose, whereas in the case of water solutions with pH = 7 and 12 the anomalous and case I diffusion are observed, respectively.

Keywords

EN

82.70.Gg; 76.60.Pc

Discipline

• 82.70.Gg: Gels and sols
• 76.60.Pc: NMR imaging(for medical NMR imaging, see 87.61.-c)

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2005
• Volume: 108
• Issue: 1
• Pages: 197-205

Dates

published

2005-07

received

2005-04-24

Contributors

author

J. Tritt-Goc

• Institute of Molecular Physics, Polish Academy of Sciences, Smoluchowskiego 17, 60-179 Poznań, Poland

author

J. Kowalczuk

• Institute of Molecular Physics, Polish Academy of Sciences, Smoluchowskiego 17, 60-179 Poznań, Poland

author

N. Piślewski

• Institute of Molecular Physics, Polish Academy of Sciences, Smoluchowskiego 17, 60-179 Poznań, Poland

References

• 1. K. Mitchell, J.L. Ford, D.J. Armstrong, P.N.C. Elliott, C. Rostron, J.E. Hogan, Int. J. Pharm., 66, 233, 1990
• 2. R. Bowtell, J.C. Sharp, A. Peters, P. Mansfield, A.R. Rajabi-Siahboomi, M.C. Davies, C.D. Melia, Magn. Reson. Imag., 12, 361, 1994
• 3. V. Michailova, S. Titeva, R. Kotsilkova, E. Krusteva, E. Minkov, Int. J. Pharm., 222, 7, 2001
• 4. P. Gao, E. Fagerness, Pharm. Res., 12, 955, 1995
• 5. B. Madhu, J. Hjartstam, B. Soussi, J. Control. Release, 56, 95, 1998
• 6. J. Tritt-Goc, N. Piślewski, J. Control Release, 80, 79, 2002
• 7. J. Tritt-Goc, J. Kowalczuk, N. Piślewski, J. Pharm. Pharmacol., 55, 1487, 2003
• 8. J. Kowalczuk, J. Tritt-Goc, N. Piślewski, Solid State NMR, 25, 35, 2004
• 9. E. Rinaki, G. Valsami, P. Machereas, Int. J. Pharm., 255, 199, 2003
• 10. M. Kojima, H. Nakagami, Chem. Pharm. Bull., 50, 1621, 2002
• 11. K. Tahara, K. Yamamoto, T. Nishihata, J. Control. Release, 35, 59, 1995
• 12. T. Ishikawa, Y. Watanabe, K. Takayama, H. Endo, M. Matsumoto, Int. J. Pharm., 202, 173, 2000
• 13. S. Baumgartner, G. Lahajnar, A. Sepe, J. Kristl, AAAPS Pharm. Sci. Tech., 3, 36, 2002
• 14. P.T. Callaghan, Principles of Nuclear Magnetic Resonance Microscopy, Oxford Sci. Publ, New York 1991
• 15. B. Blumich, NMR Imaging of Materials, Oxford Sci. Publ., New York 2000
• 16. R. Kimich, NMR Tomography, Diffusometry, Relaxometry, Springer, Heidelberg 1997
• 17. S. Meiboom, D. Gill, Rev. Sci. Instrum., 2, 688, 1958
• 18. T. Alfrey, E.F. Gurnee, W.G. Lloyd, J. Polym. Sci. C, 12, 249, 1966
• 19. M. Ercken, P. Adriaensens, G. Reggers, R. Carleer, D. Vanderzande, J. Gelan, Macromolecules, 29, 71, 1996
• 20. P.I. Ritger, N.A. Peppas, J. Control Release, 5, 37, 1987
• 21. S. Ganapathy, P.R. Rajamohanan, M.V. Badiger, A.B. Mandhare, R.A. Mashelkar, Polymer, 41, 4543, 2000
• 22. G. Smyth, F.X. Quinn, J. McBrierty, Macromolecules, 21, 3198, 1988
• 23. Y.K. Sung, D.E. Gregonis, M.S. John, J.D. Andrade, J. Appl. Polym. Sci., 26, 3719, 1981
• 24. A. Yamada-Nosaka, K. Ishikiriyama, M. Todoki, J. Appl. Polym. Sci., 39, 2443, 1990
• 25. F.X. Quinn, V.J. McBrierty, A.C. Wilson, Macromolecules, 23, 4576, 1990
• 26. R. Barbieri, M. Quaglia, M. Delfini, E. Brosio, Polymer, 39, 1059, 1998
• 27. W.E. Roorda, J. De Bleyser, H.E. Junginger, J.C. Leyte, Biomaterials, 11, 17, 1990
• 28. G.P. Lewis, W. Derbyshire, Carbohyd. Res., 160, 367, 1987
• 29. B.P. Hills, K.M. Wright, P.S. Belton, Mag. Reson. Imag., 8, 755, 1990

Identifiers

DOI

10.12693/APhysPolA.108.197