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2005 | 108 | 1 | 197-205
Article title

Hydration of Hydroxypropylmethyl Cellulose: Effects of pH and Molecular Mass

Content
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EN
Abstracts
EN
Magnetic resonance imaging was used to study the diffusion of a water solution of hydrochloric acid (HCl) and sodium hydrochloride (NaOH) into hydroxypropylmethyl cellulose matrices. Polymer in the form of a cylinder was hydrated in a water solvent of pH = 2, 7, and 12 at 37ºC and monitored at equal intervals with a 300 MHz Bruker AVANCE. The spatially resolved spin-spin relaxations times and spin densities, along with a change in the dimension of the glass core of the polymer were determined for hydroxypropylmethyl cellulose tablets as a function of hydration times. The data showed the effects of the pH solvent and of the molecular mass of the polymer on the swelling process, spin-spin relaxation time, and diffusion of solvent molecules into hydroxypropylmethyl cellulose matrices. The time dependence of the diffusion front, effective T_2, and proton-density ρ analysis clearly indicate a case II diffusion mechanism in the system composed of a water solution of hydrochloric acid (pH = 2) and hydroxypropylmethyl cellulose, whereas in the case of water solutions with pH = 7 and 12 the anomalous and case I diffusion are observed, respectively.
Keywords
EN
Year
Volume
108
Issue
1
Pages
197-205
Physical description
Dates
published
2005-07
received
2005-04-24
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-appv108n125kz
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