Mutant HIV-1 Protease Complexed with Tetrapeptide Inhibitor. Preliminary Report

• Authors: T. Skálová , J. Hašek , J. Dohnálek , H. Petroková , E. Buchtelová
• Languages of publication: EN

Abstracts

EN

The paper presents preliminary description of structure determination of a mutant form of HIV-1 protease in a complex with a new pseudotetrapeptide inhibitor that retains its high affinity to this mutant enzyme (A71V, V82T, I84V). A highly efficient microdiffractometer installed for our experiment at the beamline ID14-1 enabled us to collect satisfactory data with crystal dimensions of about 40 micrometers.

Keywords

EN

87.15.By

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2002
• Volume: 101
• Issue: 5
• Pages: 659-663

Dates

published

2002-05

received

2001-08-31

Contributors

author

T. Skálová

• Institute of Macromolecular Chemistry AS CR, Heyrovskeho nam. 2, 162 06 Prague 6, Czech Republic

author

J. Hašek

• Institute of Macromolecular Chemistry AS CR, Heyrovskeho nam. 2, 162 06 Prague 6, Czech Republic

author

J. Dohnálek

• Institute of Macromolecular Chemistry AS CR, Heyrovskeho nam. 2, 162 06 Prague 6, Czech Republic

author

H. Petroková

• Institute of Macromolecular Chemistry AS CR, Heyrovskeho nam. 2, 162 06 Prague 6, Czech Republic

author

E. Buchtelová

• Faculty of Science, Charles University, Prague, Czech Republic

References

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Identifiers

DOI

10.12693/APhysPolA.101.659