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2002 | 101 | 5 | 659-663
Article title

Mutant HIV-1 Protease Complexed with Tetrapeptide Inhibitor. Preliminary Report

Content
Title variants
Languages of publication
EN
Abstracts
EN
The paper presents preliminary description of structure determination of a mutant form of HIV-1 protease in a complex with a new pseudotetrapeptide inhibitor that retains its high affinity to this mutant enzyme (A71V, V82T, I84V). A highly efficient microdiffractometer installed for our experiment at the beamline ID14-1 enabled us to collect satisfactory data with crystal dimensions of about 40 micrometers.
Keywords
EN
Year
Volume
101
Issue
5
Pages
659-663
Physical description
Dates
published
2002-05
received
2001-08-31
References
  • 1. J. Weber, Ph.D. Thesis, Faculty of Sciences, Charles University, Prague 2001
  • 2. J. Konvalinka, J. Litera, J. Weber, J. Vondrásek, M. Hradilek, M. Soucek, I.Pichová, P. Majer, P. Strop, J. Sedlácek, A.M. Heuser, H. Kottler, H.G. Krausslich, Eur. J. Biochem., 250, 559, 1997
  • 3. T. Skálová, J. Hasek, J. Dohnálek, H. Petroková, E. Buchtelová, Mater. Struct., 8, 29, 2001
  • 4. J. Dohnálek, J. Hasek, J. Dusková, H. Petroková, M. Hradilek, M. Soucek, J. Konvalinka, J. Brynda, J. Sedlácek, J. Fábry, Acta Crystallogr. D, 57, 472, 2001
  • 5. Z. Otwinowski, in: Proc. CCP4 Study Weekend: Data Collection and Processing, Eds. L. Sawyer, N. Isaacs, S. Bailey, SERC Daresbury Laboratory, Daresbury 1993, p. 56
  • 6. The CCP4 Suite: Programs for Protein Crystallography, Acta Crystallogr. D, 50, 760, 1994
  • 7. A.T. Brunger, P.D. Adams, G.M. Clore, W.L. Delano, P. Gros, R.W. Grosse-Kunstleve, J.-S. Jiang, J. Kuszewski, N. Nilges, N.S. Pannu, R.J. Read, L.M. Rice, T. Simonson, G.L. Warren, Acta Crystallogr. D, 54, 905, 1998
  • 8. T.A. Jones, M. Kjeldgaard, Manual for O version 5.9, Department of Molecular Biology, BMC, Uppsala University, Sweden; Department of Chemistry, Aarhus University, Denmark 1993
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-appv101n511kz
Identifiers
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