Structural Genomics in Europe and beyond - Shifting Scientific Directions at EMBL Hamburg

• Authors: M. Wilmanns
• Languages of publication: EN

Abstracts

EN

The emerging structural genomics initiatives provide novel opportunities to complement the rapidly increasing amount of genomic sequence data with the three-dimensional molecular structures of the coded genes. Many of these gene products exert their cellular functions by interacting with multiple partners. Unravelling the molecular structures of these interactions provides the most useful information to investigate their involvement in cellular processes. To this end, the determination of structures exceeds the number of coded gene products by several orders of magnitude. Structural genomics offers opportunities to synergise European research in structural biology technologies, with a multitude of excellent centres currently available. In this contribution, current initiatives of the Hamburg Outstation of the European Molecular Biology Laboratory will be outlined.

Keywords

EN

87.15.-v

Discipline

• 87.15.-v: Biomolecules: structure and physical properties(for NMR of biomolecules, see 82.56.Pp)

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2002
• Volume: 101
• Issue: 5
• Pages: 635-646

Dates

published

2002-05

received

2001-08-31

Contributors

author

M. Wilmanns

• EMBL Hamburg Outstation c/o DESY, Notkestrasse 85, 22603 Hamburg, Germany

References

• 1. T.C. Terwilliger, Nat. Struct. Biol., 7 Suppl., 935, 2000
• 2. U. Heinemann, Nat. Struct. Biol., 7 Suppl., 940, 2000
• 3. S. Yokoyama, H. Hirota, T. Kigawa, T. Yabuki, M. Shirouzu, T. Terada, Y. Ito, Y. Matsuo, Y. Kuroda, Y. Nishimura, Y. Kyogoku, K. Miki, R. Masui, S. Kuramitsu, Nat. Struct. Biol., 7 Suppl., 943, 2000
• 4. J.C. Norvell, A.Z. Machalek, Nat. Struct. Biol., 7 Suppl., 931, 2000
• 5. U. Heinemann, J. Frevert, K. Hofmann, G. Illing, C. Maurer, H. Oschkinat, W. Saenger, Prog. Biophys. Mol. Biol., 73, 347, 2000
• 6. D. Christendat, A. Yee, A. Dharamsi, Y. Kluger, A. Savchenko, J.R. Cort, V. Booth, C.D. Mackereth, V. Saridakis, I. Ekiel, G. Kozlov, K.L. Maxwell, N. Wu, L.P. McIntosh, K. Gehring, M.A. Kennedy, A.R. Davidson, E.F. Pai, M. Gerstein, A.M. Edwards, C.H. Arrowsmith, Nat. Struct. Biol., 7, 903, 2000
• 7. A.M. Edwards, C.H. Arrowsmith, D. Christendat, A. Dharamsi, J.D. Friesen, J.F. Greenblatt, M. Vedadi, Nat. Struct. Biol., 7 Suppl., 970, 2000
• 8. J.P. Renaud, D. Moras, Cell. Mol. Life Sci., 57, 1748, 2000
• 9. S. Sunyaev, W. Lathe III, P. Bork, Curr. Opin. Struct. Biol., 11, 125, 2001
• 10. Y. Ho, A. Gruhler, A. Heilbut, G.D. Bader, L. Moore, S.L. Adams, A. Millar, P. Taylor, K. Bennett, K. Boutilier, L. Yang, C. Wolting, I. Donaldson, S. Schandorff, J. Shewnarane, M. Vo, J. Taggart, M. Goudreault, B. Muskat, C. Alfarano, D. Dewar, Z. Lin, K. Michalickova, A.R. Willems, H. Sassi, P.A. Nielsen, K.J. Rasmussen, J.R. Andersen, L.E. Johansen, L.H. Hansen, H. Jespersen, A. Podtelejnikov, E. Nielsen, J. Crawford, V. Poulsen, B.D. Sorensen, J. Matthiesen, R.C. Hendrickson, F. Gleeson, T. Pawson, M.F. Moran, D. Durocher, M. Mann, C.W. Hogue, D. Figeys, M. Tyers, Nature, 415, 180, 2002
• 11. A.C. Gavin, M. Bosche, R. Krause, P. Grandi, M. Marzioch, A. Bauer, J. Schultz, J.M. Rick, A.M. Michon, C.M. Cruciat, M. Remor, C. Hofert, M. Schelder, M. Brajenovic, H. Ruffner, A. Merino, K. Klein, M. Hudak, D. Dickson, T. Rudi, V. Gnau, A. Bauch, S. Bastuck, B. Huhse, C. Leutwein, M.A. Heurtier, R.R. Copley, A. Edelmann, E. Querfurth, V. Rybin, G. Drewes, M. Raida, T. Bouwmeester, P. Bork, B. Seraphin, B. Kuster, G. Neubauer, G. Superti-Furga, Nature, 415, 141, 2002
• 12. P.J. Hajduk, R.P. Meadows, S.W. Fesik, Q. Rev. Biophys., 32, 211, 1999
• 13. A. Perrakis, R. Morris, V.S. Lamzin, Nat. Struct. Biol., 6, 458, 1999
• 14. D.I. Svergun, M.V. Petoukhov, M.H. Koch, Biophys. J., 80, 2946, 2001
• 15. J. Trinick, L. Tskhovrebova, Trends. Cell. Biol., 9, 377, 1999
• 16. S. Labeit, B. Kolmerer, Science, 270, 293, 1995
• 17. M.L. Bang, T. Centner, F. Fornoff, A.J. Geach, M. Gotthardt, M. McNabb, C.C. Witt, D. Labeit, C.C. Gregorio, H. Granzier, S. Labeit, Circ. Res., 89, 1065, 2001
• 18. J.M. Squire, Curr. Opin. Struct. Biol., 7, 247, 1997
• 19. W.A. Linke, Adv. Exp. Med. Biol., 481, 179, 2000
• 20. M. Pfuhl, A. Pastore, Structure, 3, 391, 1995
• 21. R.A. Atkinson, C. Joseph, G. Kelly, F.W. Muskett, T.A. Frenkiel, D. Nietlispach, A. Pastore, Nat. Struct. Biol., 8, 853, 2001
• 22. O. Mayans, J. Wuerges, S. Canela, M. Gautel, M. Wilmanns, Structure, 9, 331, 2001
• 23. S. Improta, A.S. Politou, A. Pastore, Structure, 4, 323, 1996
• 24. C. Muhle-Goll, M. Nilges, A. Pastore, J. Biomol. NMR, 92, 1997
• 25. O. Mayans, P.F. van der Ven, M. Wilm, A. Mues, P. Young, D.O. Furst, M. Wilmanns, M. Gautel, Nature, 395, 863, 1998
• 26. P.E. Marszalek, H. Lu, H. Li, M. Carrion-Vazquez, A.F. Oberhauser, K. Schulten, J.M. Fernandez, Nature, 402, 100, 1999
• 27. G.M. Benian, X. Tang, T.L. Tinley, Adv. Biophys., 33, 183, 1996
• 28. F. Fraternali, A. Pastore, J. Mol. Biol., 290, 581, 1999
• 29. C.C. Witt, N. Olivieri, T. Centner, B. Kolmerer, S. Millevoi, J. Morell, D. Labeit, S. Labeit, H. Jockusch, A. Pastore, J. Struct. Biol., 122, 206, 1998
• 30. S.T. Cole, R. Brosch, J. Parkhill, T. Garnier, C. Churcher, D. Harris, S.V. Gordon, K. Eiglmeier, S. Gas, C.E. Barry III, F. Tekaia, K. Badcock, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. Davies, K. Devlin, T. Feltwell, S. Gentles, N. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, A. Krogh, J. McLean, S. Moule, L. Murphy, K. Oliver, J. Osborne, M.A. Quail, M.-A. Rajandream, J. Rogers, S. Rutter, K. Seeger, J. Skelton, R. Squares, S. Squares, J.E. Sulson, K. Taylor, S. Whitehead, B.G. Barrell, Nature, 393, 537, 1998

Identifiers

DOI

10.12693/APhysPolA.101.635