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Number of results
2018 | 133 | 2 | 250-255

Article title

Novel Aminoketooxime Ligand and Its Cu(II) and Mn(II) Complexes: Synthesis, Characterization and Molecular Docking Studies

Content

Title variants

Languages of publication

EN

Abstracts

EN
A novel ligand, N,N"-(4-methyl-1,2-phenylene)bis(2-(biphenyl-4-yl)-N'-hydroxy-2-oxoacetimidamide) (H₂L) with its Cu(II) and Mn(II) complexes were synthesized in this study. All compounds synthesized were also characterized by ¹H- and ¹³C-NMR, the Fourier transform infrared, elemental analysis, inductively coupled plasma optical emission spectrometry, molar conductivity, magnetic susceptibility measurements and thermogravimetric analysis. Vascular endothelial growth factor-2 (VEGFR-2) and cyclooxygenase-2 (COX-2) inhibition is often used as a parameter for being a potent anticancer agent in docking studies. For this purpose, synthesized and characterized ligand was investigated by molecular docking study to test its inhibitory effect against angiogenic factors VEGFR-2 and COX-2.

Year

Volume

133

Issue

2

Pages

250-255

Physical description

Dates

published
2018-02

Contributors

author
  • Faculty of Education, Mehmet Akif Ersoy University, Burdur, Turkey
author
  • Faculty of Science and Arts, Süleyman Demirel University, Isparta, Turkey
author
  • Faculty of Science and Arts, Süleyman Demirel University, Isparta, Turkey

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-app133z2p09kz
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