Novel Aminoketooxime Ligand and Its Cu(II) and Mn(II) Complexes: Synthesis, Characterization and Molecular Docking Studies

• Authors: G. Gorgulu , M. Cicek , B. Dede
• Languages of publication: EN

Abstracts

EN

A novel ligand, N,N"-(4-methyl-1,2-phenylene)bis(2-(biphenyl-4-yl)-N'-hydroxy-2-oxoacetimidamide) (H₂L) with its Cu(II) and Mn(II) complexes were synthesized in this study. All compounds synthesized were also characterized by ¹H- and ¹³C-NMR, the Fourier transform infrared, elemental analysis, inductively coupled plasma optical emission spectrometry, molar conductivity, magnetic susceptibility measurements and thermogravimetric analysis. Vascular endothelial growth factor-2 (VEGFR-2) and cyclooxygenase-2 (COX-2) inhibition is often used as a parameter for being a potent anticancer agent in docking studies. For this purpose, synthesized and characterized ligand was investigated by molecular docking study to test its inhibitory effect against angiogenic factors VEGFR-2 and COX-2.

Keywords

EN

oxime; dinuclear complex; antiferromagnetic; docking; VEGFR-2; COX-2

• Journal: Acta Physica Polonica A
• Year: 2018
• Volume: 133
• Issue: 2
• Pages: 250-255

Dates

published

2018-02

Contributors

author

G. Gorgulu

• Faculty of Education, Mehmet Akif Ersoy University, Burdur, Turkey

author

M. Cicek

• Faculty of Science and Arts, Süleyman Demirel University, Isparta, Turkey

author

B. Dede

• Faculty of Science and Arts, Süleyman Demirel University, Isparta, Turkey

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Identifiers

DOI

10.12693/APhysPolA.131.250