PL EN


Preferences help
enabled [disable] Abstract
Number of results
2018 | 133 | 2 | 250-255
Article title

Novel Aminoketooxime Ligand and Its Cu(II) and Mn(II) Complexes: Synthesis, Characterization and Molecular Docking Studies

Content
Title variants
Languages of publication
EN
Abstracts
EN
A novel ligand, N,N"-(4-methyl-1,2-phenylene)bis(2-(biphenyl-4-yl)-N'-hydroxy-2-oxoacetimidamide) (H₂L) with its Cu(II) and Mn(II) complexes were synthesized in this study. All compounds synthesized were also characterized by ¹H- and ¹³C-NMR, the Fourier transform infrared, elemental analysis, inductively coupled plasma optical emission spectrometry, molar conductivity, magnetic susceptibility measurements and thermogravimetric analysis. Vascular endothelial growth factor-2 (VEGFR-2) and cyclooxygenase-2 (COX-2) inhibition is often used as a parameter for being a potent anticancer agent in docking studies. For this purpose, synthesized and characterized ligand was investigated by molecular docking study to test its inhibitory effect against angiogenic factors VEGFR-2 and COX-2.
Publisher

Year
Volume
133
Issue
2
Pages
250-255
Physical description
Dates
published
2018-02
Contributors
author
  • Faculty of Education, Mehmet Akif Ersoy University, Burdur, Turkey
author
  • Faculty of Science and Arts, Süleyman Demirel University, Isparta, Turkey
author
  • Faculty of Science and Arts, Süleyman Demirel University, Isparta, Turkey
References
  • [1] R.H. Crabtree, The Organometallic Chemistry of the Transition Metals, 4th ed., Wiley, Hoboken (NJ) 2005
  • [2] M. Lahlou, Pharmacol. Pharm. 4, 17 (2013), doi: 10.4236/pp.2013.43A003
  • [3] A.S. El-Tabl, M.M. Abd El-Waheed, M.A. Wahba, N.A.E.A. El-Fadl, Bioinorg. Chem. Appl. 2015, 126023 (2015), doi: 10.1155/2015/126023
  • [4] H. Dai, G. Li, J. Chen, Y. Shi, S. Ge, C. Fan, H. He, Bioorg. Med. Chem. Lett. 26, 3818 (2016), doi: 10.1155/2015/126023
  • [5] A. Colak, U. Terzi, M. Col, Ş.A. Karaoglu, S. Karaböcek, A. Küçükdumlu, F.A. Ayaz, Eur. J. Med. Chem. 45, 5169 (2010), doi: 10.1016/j.ejmech.2010.08.031
  • [6] P. Nirmala, M. Ramanathan, Eur. J. Pharmacol. 654, 75 (2011), doi: 10.1016/j.ejphar.2010.11.034
  • [7] R. Wang, X. Zhang, H. Song, S. Zhou, S. Li, Bioorg. Med. Chem. Lett. 24, 4304 (2014), doi: 10.1016/j.bmcl.2014.07.012
  • [8] L.M. Ellis, D.J. Hicklin, Nat. Rev. Cancer 8, 579 (2008), doi: 10.1038/nrc2403
  • [9] J.E. Huh, J.W. Kang, D. Nam, Y.H. Baek, D.Y. Choi, D.S. Park, J.D. Lee, J. Nat. Prod. 75, 1922 (2012), doi: 10.1021/np300446c
  • [10] A. Grosdidier, V. Zoete, O. Michielin, Nucleic Acids Res. 39, W270 (2011), doi: 10.1093/nar/gkr366
  • [11] 1-Click Docking http://mcule.com/apps/1-click-docking/
  • [12] O. Trott, A.J. Olson, J. Comput. Chem. 31, 455 (2010), doi: 10.1002/jcc.21334
  • [13] N. Levin, W.H. Hartung, J. Org. Chem. 7, 408 (1942), doi: 10.1021/jo01199a002
  • [14] M.J. Prushan, A.W. Addison, R.J. Butcher, L.K. Thompson, Inorg. Chim. Acta 358, 3449 (2005), doi: 10.1016/j.ica.2005.04.038
  • [15] S.Y. Uçan, B. Mercimek, Synt. React. Inorg. Met. 35, 197 (2005), doi: 10.1081/SIM-200037249
  • [16] C.O. Sanchez, C.J. Bustos, F.A. Alvarado, N. Gatica, N. Fernandez, Polymer Bull. 57, 505 (2006), doi: 10.1007/s00289-006-0575-6
  • [17] D. Steinborn, M. Rausch, C. Bruhn, J. Organomet. Chem. 561, 191 (1998), doi: 10.1016/S0022-328X(98)00534-8
  • [18] A. Kılıç, E. Taş, B. Gümgüm, İ. Yılmaz, Transit. Met. Chem. 31, 645 (2006), doi: 10.1007/s11243-006-0043-z
  • [19] P.E. Aranha, M.P. dos Santos, S. Romera, E.R. Dockal, Polyhedron 26, 1373 (2007), doi: 10.1016/j.poly.2006.11.005
  • [20] N. Sarı, N. Yüzüak, J. Inorg. Organomet. Polym. Mater. 16, 259 (2006), doi: 10.1007/s10904-006-9056-5
  • [21] W.J. Geary, Coord. Chem. Rev. 7, 81 (1971), doi: 10.1016/S0010-8545(00)80009-0
  • [22] R. Ruiz, F. Lloret, M. Julve, J. Faus, M.C. Munoz, X. Solans, Inorg. Chim. Acta 213, 261 (1993), doi: 10.1016/S0020-1693(00)83836-0
  • [23] D. Luneau, H. Oshio, H. Okawa, M. Koikawa, S. Kida, Bull. Chem. Soc. Jpn. 63, 2212 (1990), doi: 10.1246/bcsj.63.2212
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-app133z2p09kz
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.