Preferences help
enabled [disable] Abstract
Number of results
2018 | 65 | 1 | 9-15
Article title

Tips for optimizing organ preservation solutions

Title variants
Languages of publication
Organ injury during ischemia is one of the clinical problems of today's transplantation. It occurs during warm ischemia time (WIT) when the blood flow is cut off and during cold ischemia when a graft is chilled in situ until the circulation is restored to the recipient organism. Fast cooling of the organ slows down metabolism and activates intracellular enzymes, which minimizes the effects of warm ischemia. Unfortunately, hypothermia also results in inhibition of ATP synthesis, cell swelling and intracellular acidity. That is why research is continually being conducted to develop new fluids for rinsing and storing organs, as well as to optimize the composition of those that are already in use, which will allow for longer and more effective graft storage and restoration of their optimal functions after transplantation. This article provides current information on rinsing and storage fluids available on the global market. It also discusses tips for the fluid modifications with hormones and micronutrients.
Physical description
  • Department of Pharmaceutical Technology, Chair of Applied Pharmacy, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland
  • Department of Pharmaceutical Technology, Chair of Applied Pharmacy, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland
  • "Biochefa" Pharmaceutical Research and Production Plant, Sosnowiec, Poland
  • "Biochefa" Pharmaceutical Research and Production Plant, Sosnowiec, Poland
  • Aldemir M, Karatepe C, Baki ED, Çarşanba G, Tecer E (2014) Comparison of plegisol and modified ST Thomas Hospital cardioplegic solution in the development of ventricular fibrillation after declamping of the aorta. World J Card Surg 4: 159-166. doi: 10.4236/wjcs.2014.410023
  • Aslaner A, Gunal O, Turgut HT, Celik E, Yildirim U, Demirci RK, Gunduz UR, Calis H, Dogan S (2013) Effect of melatonin on kidney cold ischemic preservation injury. Int J Clin Exp Med 6: 794-798.
  • Badet L, Abdennebi HB, Petruzzo P, McGregor B, Espa M, Hadj-Aissa A, Ramella-Virieux S, Steghens JP, Portoghese F, Morelon E, Martin X (2005) Evaluation of IGL-1, a new organ preservation solution: preclinical results in renal transplantation. Prog Urol 15: 481-488.
  • Bando T, Albes JM, Nüsse T, Wada H, Hitomi S, Wahlers T, Schäfers H (1998) Comparison of euro-collins solution, low-potassium dextran solution containing glucose, and ET-kyoto solution for lung preservation in an extracorporeal rat lung perfusion model. Eur Surg Res 30: 297-304.
  • Ben Abdennebi H, Steghens JP, Hadj-Aïssa A, Barbieux A, Ramella-Virieux S, Gharib C, Boillot O (2002) A preservation solution with polyethylene glycol and calcium: a possible multiorgan liquid. Transpl Int 15: 348-354. doi: 10.1007/s00147-002-0427-8.
  • Bessems M, Doorschodt BM, Albers PS, van Vliet AK, van Gulik TM (2005a) Wash-out of the non-heart-beating donor liver: a comparison between ringer lactate, HTK, and Polysol. Transplant Proc 37: 395-398. doi: 10.1016/j.transproceed.2004.12. 260.
  • Bessems M, Doorschodt BM, van Vliet AK, van Gulik TM (2005b) Improved rat liver preservation by hypothermic continuous machine perfusion using Polysol a new, enriched preservation solution. Liver Transpl 11: 539 -546. doi: 10.1002/lt.20388.
  • Beyer CE, Steketee JD, Saphier D (1998) Antioxidant properties of melatonin - an emerging mystery. Biochem Pharmacol 56: 1265-1272.
  • Birks E, Burton P, Owen V, Latif N, Nyawo B, Yacoub M (2001) Molecular and cellular mechanisms of donor heart dysfunction. Transplant Proc 33: 2749-2751.
  • Budziński G, Suszka-Świtek A, Roman P, Caban A, Oczkowicz A, Mały A, Wiaderkiewicz R, Smorąg Z, Ryszka F, Cierpka L (2014a) Interleukin-6 concentration in the transgenic pig's liver preserved for 24 hours in Biolasol solution. Transplant Proc 46: 2552-2554. doi: 10.1016/j.transproceed.2014.09.047.
  • Budziński G, Suszka-Świtek A, Roman P, Caban A, Oczkowicz A, Czech E, Mały A, Wiaderkiewicz R, Smorąg Z, Ryszka F, Cierpka L (2014) Cytochrome P450 3 A expression in pigs livers after 24 hour preservation in Biolasol solution depending on the type of transgenesis. Transplant Proc 46: 2548-2551. doi: 10.1016/ j.transproceed.2014.09.046.
  • Caban A, Oczkowicz G, Budziński G, Suszka-Świtek A, Dolińska B, Ostróżka-Cieślik A, Wieczorek J, Ryszka F, Wiaderkiewicz R, Cierpka L (2014) Toll-like receptors 2 and 4 in pigs, kidneys early after autotransplantation procedure. Transplant Proc 46: 2545-2547. doi: 10.1016/j.transproceed.2014.09.035.
  • Cannata A, Botta L, Colombo T, Russo CF, Taglieri C, Bruschi G, Merlanti B, Frigerio M, Martinelli L (2012) Does the cardioplegic solution have an effect on early outcomes following heart transplantation? Eur J Cardiothorac Surg 41: e48-e52. doi: 10.1093/ejcts/ezr321.
  • Carrillo-Vico A, Lardone PJ, Fernandez-Santos J (2005) Human lymphocyte-synthesized melatonin is involved in the regulation of the IL-2/IL-2 receptor system. J Clin Endocrinol Metab 90: 992-1000. doi: 10.1210/jc.2004-1429.
  • Cervinková Z, Svátková R, Kalous M, Rauchová H, Cervinka M, Drahota Z (1998) Effect of triiodothyronine administration on the recovery of liver oxidative capacity after partial hepatectomy. Eur Surg Res 30: 371-377.
  • Charoenphandhu N, Krishnamra N (2007) Prolactin is an important regulator of intestinal calcium transport. Can J Physiol Pharmacol 85: 569-581. doi: 10.1139/y07-041.
  • Charoenphandhu N, Limlomwongse L, Krishnamra N (2001) Prolactin directly stimulates transcellular active calcium transport in the duodenum of female rats. Can J Physiol Pharmacol 79: 430-438.
  • Chen F, Nakamura T, Wada H (2004) Development of new organ preservation solutions in Kyoto University. Yonsei Med J 45: 1107-1114. doi: 10.3349/ymj.2004. 45.6.1107.
  • Cierpka L, Ryszka F, Dolińska B, Smorąg Z, Słomski R, Wiaderkiewicz R, Caban A, Budziński G, Oczkowicz G, Wieczorek J (2014) Biolasol: Novel perfusion and preservation solution for kidneys. Transplant Proc 46: 2539-2541. doi: 10.1016/j.transproceed.2014.09.016.
  • Codas R, Petruzzo P, Morelon E, Lefrançois N, Danjou F, Berthillot C, Contu P, Espa M, Martin X, Badet L (2009) IGL-1 solution in kidney transplantation: first multicenter study. Clin Transplant 23: 337-342. doi: 10.1111/j.1399-0012.2009.00959.x.
  • Dolińska B, Łopata K, Ryszka F (2012) Prolactin and other regulators of calcium absorption. Ann Acad Med Siles 66: 52-56
  • Dolińska B, Ostróżka-Cieślik A, Caban A, Cierpka L, Ryszka F (2012) Comparing the effect of Biolasol® and HTK solutions on maintaining proper homeostasis indicating the kidney storage efficiency prior to transplantation. Ann Transplant 17: 74-78.
  • Dondero F, Paugam-Burtz C, Danjou F, Stocco J, Durand F, Belghiti J (2010) A randomized study comparing IGL-1 to the University of Wisconsin preservation solution in liver transplantation. Ann Transplant 15: 7-14.
  • Dutheil D, Underhaug Gjerde A, Petit-Paris I, Mauco G, Holmsen H (2009) Polyethylene glycols interact with membrane glycerophospholipids: is this part of their mechanism for hypothermic graft protection? J Chem Biol 2: 39-49. doi: 10.1007/s12154-009-0014-x.
  • Eipel C, Hübschmann U, Abshagen K, Wagner KF, Menger MD, Vollmar B (2012) Erythropoietin as additive of HTK preservation solution in cold ischemia/reperfusion injury of steatotic livers. J Surg Res 173: 171-179. doi: 10.1016/j.jss.2010.09.008.
  • Ferng AS, Schipper D, Connell AM, Marsh KM, Knapp S, Khalpey Z (2017) Novel vs clinical organ preservation solutions: improved cardiac mitochondrial protection. J Cardiothorac Surg 12: 7. doi: 10.1186/s13019-017-0564-x.
  • Filus A, Zdrojewicz Z (2014) Insulin-like growth factor-1 (IGF-1) - structure and the role in the human body. Pediatr Endocrinol Diabetes Metab 20: 161–169. doi: 10.18544/PEDM-20.04.0016.
  • Forsythe JLR (2001) Transplantation Surgery. Harcourt Publishers. London
  • Franco-Gou R, Mosbah IB, Serafin A, Abdennebi HB, Roselló-Catafau J, Peralta C (2007) New preservation strategies for preventing liver grafts against cold ischemia reperfusion injury. J Gastroenterol Hepatol 22: 1120-1126. doi: 10.1111/j.1440-1746.2006.04495.x.
  • Gohrbandt B, Simon AR, Warnecke G, Fischer S, Hagl C, Niehaus A, Gottlieb J, Welte T, Haverich A, Strueber M (2015) Lung Preservation With Perfadex or Celsior in Clinical Transplantation: A Retrospective Single-Center Analysis of Outcomes. Transplantation 99: 1933-1939. doi: 10.1097/TP.0000000000000578.
  • Golisz M (2013) HES - 'bad boy' of fluid resuscitation. Anest Ratow 7: 404–408
  • Guibert EE, Petrenko AY, Balaban CL, Somov AY, Rodriguez JV, Fuller BJ (2011) Organ preservation: current concepts and new strategies for the next decade. Transfus Med Hemother 38: 125-142. doi: 10.1159/000327033.
  • Gunal O, Cokun A, Aslaner A, Yildirim U (2010) Does melatonin alleviate cold preservation injury of the liver? Turk J Med Sci 40: 465-470
  • Hata K, Tolba RH, Wei L, Doorschodt BM, Büttner R, Yamamoto Y, Minor T (2007) Impact of Polysol, a newly developed preservation solution, on cold storage of steatotic rat livers. Liver Transpl 13: 114 -121. doi: 10.1002/lt.20957.
  • Hauet T, Mothes D, Goujon JM, Carretier M, Eugene M (2001) Protective effect of polyethylene glycol against prolonged cold ischemia and reperfusion injury: study in the isolated perfused rat kidney. J Pharmacol Exp Ther 297: 946-952.
  • Imberti R, Vairetti M, Gualea MR, Feletti F, Poma G, Richelmi P, Preseglio I, Bellomo G (1998) The effects of thyroid hormone modulation on rat liver injury associated with ischemia-reperfusion and cold storage. Anesth Analg 86: 1187-1193.
  • Jackevicius CA, Fan CS, Warner A (2014) Clinical outcomes of erythropoietin use in heart failure patients with anemia of chronic kidney disease. J Card Fail 20: 327-333.
  • Jaworek J, Nawrot-Porabka K, Leja-Szpak A, Bonior J, Szklarczyk J, Kot M, Konturek SJ, Pawlik WW (2007) Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. J Physiol Pharmacol 58: 65-80.
  • Jóżwik A, Domagała P, Kieszek R, Wszoła M, Bieniasz M, Serwańska-Swetek M, Durlik M, Ryszka F, Chmura A, Kwiatkowski A (2016) Storage kidneys prior to transplantation using first polish preservation solution 'Biolasol' - Preliminary Report. American Transplant Congress, Boston 11.06.2016, abstract.
  • Kopeć-Szlęzak J (2009) Erythroblastic islands - 50 years after discovery. J Transf Med 1: 34–39
  • Kumarasinghe G, Gao L, Hicks M, Villanueva J, Doyle A, Rao P, Ru Qiu M, Jabbour A, Iyer A, Chew HC, Hayward CS, Macdonald P (2016) Improved heart function from older donors using pharmacologic conditioning strategies. J Heart Lung Transplant 35: 636-646. doi: 10.1016/j.healun.2015.12.020.
  • Latchana N, Peck JR, Whitson B, Black SM (2014) Preservation solutions for cardiac and pulmonary donor grafts: a review of the current literature. J Thorac Dis 6: 1143-1149. doi: 10.3978/j.issn.2072-1439.2014.05.14.
  • Li Y, Guo S, Liu G, Yuan Y, Wang W, Zheng Z, Hu S, Ji B (2016) Three preservation solutions for cold storage of heart allografts: a systematic review and meta-analysis. Artif Organs 40: 489-496. doi: 10.1111/aor.12585.
  • Li Z, Nickkholgh A, Yi X, Bruns H, Gross ML, Hoffmann K, Mohr E, Zorn M, Büchler MW, Schemmer P (2009) Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF-kB and apoptosis after experimental kidney transplantation. J Pineal Res 46: 365-372. doi: 10.1111/j.1600-079X.2009.00672.x.
  • López-Burillo S, Tan DX, Mayo JC, Sainz RM, Manchester LC, Reiter RJ (2003) Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions. J Pineal Res 34: 269-277.
  • Maathuis MH, Ottens PJ, van Goor H, Zwaagstra JJ, Wiersema-Buist J, Schuurs TA, Ploeg RJ, Leuvenink HG (2008) Static cold storage preservation of ischemically damaged kidneys. a comparison between IGL-1 and Viaspan solution. Transpl Int 21: 473-482. doi: 10.1111/j.1432-2277.2007.00634.x.
  • Malik R, Mellor N, Selden C, Hodgson H (2003) Triiodothyronine enhances the regenerative capacity of the liver following partial hepatectomy. Hepatology 37: 79-86. doi: 10.1053/jhep.2003.50001.
  • Meine MH, Leipnitz I, Zanotelli ML, Schlindwein ES, Kiss G, Martini J, de Medeiros Fleck A, Mucenic M, de Mello Brandão A, Marroni CA, Craco Cantisani GP (2015) Comparison between IGL-1 and HTK preservation solutions in deceased donor liver transplantation. Transplant Proc 47: 888-893. doi: 10.1016/j.transproceed. 2015.03.033.
  • Menezes AQ, Pêgo-Fernandes PM, Cardoso PF, Braga KA, Nepomuceno NA, Pazetti R, Correia AT, Canzian M, Santim JK, Jatene FB (2012) Comparison of Celsior and Perfadex lung preservation solutions in rat lungs subjected to 6 and 12 hours of ischemia using an ex-vivo lung perfusion system. Clinics 67: 1309-1314.
  • Morariu AM, Vd Plaats A, V Oeveren W, 'T Hart NA, Leuvenink HG, Graaff R, Ploeg RJ, Rakhorst G (2003) Hyperaggregating effect of hydroxyethyl starch components and University of Wisconsin solution on human red blood cells: a risk of impaired graft perfusion in organ procurement? Transplantation 76: 37-43. doi: 10.1097/01.TP.0000068044. 84652.9F.
  • Mosbah IB, Zaouali MA, Martel C, Bjaoui M, Abdennebi HB, Hotter G, Brenner C, Roselló-Catafau J (2012) IGL-1 solution reduces endoplasmic reticulum stres and apoptosis in rat liver transplantation. Cell Death Dis 3: e279. doi: 10.1038/cddis.2012.12.
  • Ohsumi A, Marseu K, Slinger P, McRae K, Kim H, Guan Z, Hwang DM, Liu M, Keshavjee S, Cypel M (2017) Sevoflurane attenuates ischemia-reperfusion injury in a rat lung transplantation model. Ann Thorac Surg 103: 1578-1586. doi: 10.1016/j.athoracsur.2016.10.062.
  • Olazabal IM, Muñoz JA, Rodríguez-Navas C, Alvarez L, Delgado-Baeza E, García-Ruiz JP (2009) Prolactin's role in the early stages of liver regeneration in rats. J Cell Physiol 219: 626-633. doi: 10.1002/jcp.21707.
  • Ostróżka-Cieślik A, Dolinska B, Caban A, Ryszka F (2015) Effect of the addition of zinc and selenium ions on the stability of the Biolasol liquid used for perfusion, reperfusion and preservation of parenchymal organs of the abdominal cavity. J Elem 20: 377-384
  • Ostróżka-Cieślik A, Ryszka F, Dolińska B (2008) Characteristics of fluids used for perfusion and organ preservation. Ann Acad Med Siles 1: 70-75
  • Parada-Turska J, Targońska-Stępniak B, Majdan M (2006) Prolactin in connective tissue diseases. Postepy Hig Med Dosw 60: 278-285.
  • Pedotti P, Cardillo M, Rigotti P, Gerunda G, Merenda R, Cillo U, Zanus G, Baccarani U, Berardinelli ML, Boschiero L, Caccamo L, Calconi G, Chiaramonte S, Dal Canton A, De Carlis L, Di Carlo V, Donati D, Montanaro D, Pulvirenti A, Remuzzi G, Sandrini S, Valente U, Scalamogna M (2004) A comparative prospective study of two available solutions for kidney and liver preservation. Transplantation 77: 1540-1545.
  • van der Plaats A, 't Hart NA, Morariu AM, Verkerke GJ, Leuvenink H, Ploeg RJ, Rakhorst G (2004) Effect of University of Winsconsin organ-preservation solution on haemorheology. Transpl Int 17: 227-233. doi: 10.1007/s00147-004-0705-8.
  • Popławski PT, Derlacz RA (2003) How does melatonin function? Postepy Biochem 49: 9-17.
  • Powell SR, Aiuto L, Hall D, Tortolani AJ (1995) Zinc supplementation enhances the effectiveness of St. Thomas' Hospital No. 2 cardioplegic solution in an in vitro model of hypothermic cardiac arrest. J Thorac Cardiovasc Surg 110: 1642-1648. doi: 10.1016/S0022-5223(95)70025-0.
  • Rao V, Feindel CM, Cohen G, Borger MA, Boylen P, Ross HJ (2001) Is profound hypothermia required for storage of cardiac allografts? J Thorac Cardiovasc Surg 122: 501-507. doi: 10.1067/mtc.2001.115918.
  • Reiter RJ, Tan DX, Osuna C, Gitto E (2000) Actions of melatonin in the reduction of oxidative stress. J Biomed Sci 7: 444-458. doi: 10.1159/000025480.
  • Rowiński W, Wałaszewski J, Pęczak L (2004) Clinical transplantology. PZWL (in Polish)
  • Ryszka F, Cierpka L, Dolińska B (2005) A solution for organ and tissue perfusion, preservation and reperfusion. Polish Patent P: 375516
  • Ryszka F, Dolińska B, Caban A, Ostróżka-Cieślik A, Budziński G, Krzysztofik M, Oczkowicz G, Cierpka L (2011) Hepatoprotective effect of prolactin and cysteine contained in perfusion and preservation solutions on porcine liver stored in simple hypothermia. Transplant Proc 43: 2882-2886. doi: 10.1016/j.transproceed.2011.08.064.
  • Ryszka F, Dolińska B, Czyż K, Jelińska M, Strabel A, Bocheńska J (2016) Effect of Recombinant Human Prolactin Addition to Biolasol Solution on Biochemical Indicators in Perfundates of Porcine Kidneys. Transplant Proc 48: 1824-1828. doi: 10.1016/j.transproceed.2015.12.140.
  • Ryszka F, Dolińska B, Ostróżka-Cieślik A, (2006) Solutions for organs storage purposes and evaluation of their efficiency. In Biotechnological and medical aspects of xenotransplantation. Smorąg Z, Słomski R, Cierpka L eds, pp 291-303. Scientific Publishers OWN.
  • Ryszka F, Dolińska B, Suszka-Switek A (2002) Distribution of prolactin in selected rat organs and tissues. Int J Tissue React 24: 33-36.
  • Saganowska R (2008) Erythropoietin - physiological role and clinical practise. Przegl Pediatr 38: 313–318
  • Saruç M, Karaarslan M, Rasa K, Saygili O, Ince U, Baysal C, Pour PM, Cakmakçi M, Tözün N (2009) Pancreatic cancer and glucose metabolism. Turk J Gastroenterol 20: 257-260.
  • Schmeding M, Hunold G, Ariyakhagorn V, Rademacher S, Boas-Knoop S, Lippert S, Neuhaus P, Neumann UP (2009) Erythropoietin reduces ischemia-reperfusion injury after liver transplantation in rats. Transpl Int 22: 738-746. doi: 10.1111/j.1432-2277.2009.00861.x.
  • Schreinemachers MCJM (2010) Preclinical evaluation of a new organ preservation solution. University of Amsterdam
  • Schreinemachers MC, Doorschodt BM, Florquin S, van den Bergh Weerman MA, Reitsma JB, Lai W, Sitzia M, Minor TM, Tolba RH, van Gulik TM (2009a) Improved preservation and microcirculation with POLYSOL after transplantation in a porcine kidney autotransplantation model. Nephrol Dial Transplant 24: 816-824. doi: 10.1093/ndt/gfn559.
  • Schreinemachers MC, Bemelman FJ, Idu MM, van Donselaar-van der Pant KA, van de Berg PJ, Reitsma JB, Legemate DA, Florquin S, ten Berge IJ, Doorschodt BM, van Gulik TM (2013) First clinical experience with polysol solution: pilot study in living kidney transplantation. Transplant Proc 45: 38-45doi: 10.1016/j.transproceed. 2012.10.026.
  • Schreinemachers MC, Doorschodt BM, Florquin S, Idu MM, Tolba RT, van Gulik TM (2009b) Improved renal function of warm ischemically damaged kidneys using Polysol. Transplant Proc 41: 32-35. doi: 10.1016/j.transproceed.2008.08.146.
  • Soncul H, Kaptanoglu M, Öz E, Halit V, Bilgehan A, Cayci B, Gökgöz L, Türkozan N, Ersöz A (1994) The role of selenium added to pulmonary preservation solutions in isolated guinea pig lungs. J Thorac Cardiovasc Surg 108: 922-927.
  • Steffen A, Kiss T, Schmid J, Schubert U, Heinke S, Lehmann S, Bornstein S, Ludwig B, Ludwig S (2017) Production of high-quality islets from goettingen minipigs: Choice of organ preservation solution, donor pool, and optimal cold ischemia time. Xenotransplantation 24. doi: 10.1111/xen.12284.
  • Sukocheva OA, Carpenter DO (2006) Anti-apoptotic effects of 3,5,3'-tri-iodothyronine in mouse hepatocytes. J Endocrinol 191: 447-458. doi: 10.1677/joe.1.07061.
  • Szulc-Musioł B, Drózdz M, Ryszka F, Dolínska B, Scigała P (2004) The influence of prolactin on the chosen biochemical parameters of the rabbit liver in ischemia. Acta Pol Pharm 61: 477-482.
  • Treska V, Kuntscher V, Molácek J, Kobr J, Racek J, Trefil L (2003) Can ischemia-reperfusion syndrome in transplanted kidneys procured from non-heart-beating donors be influenced by adding selenium into the reperfusion solution? An experimental study. Transplant Proc 35: 3125-3127.
  • Tullius SG, Filatenkow A, Horch D, Mehlitz T, Reutzel-Selke A, Pratschke J, Steinmüller T, Lun A, Al-Abadi H, Neuhaus P (2002) Accumulation of crystal deposits in abdominal organs following perfusion with defrosted University of Wisconsin solutions. Am J Transplant 2: 627-630.
  • Vera-Lastra O, Jara LJ, Espinoza LR (2002) Prolactin and autoimmunity. Autoimmun Rev 1: 360-364.
  • Wada H, Fukuse T, Nakamura T, Liu CJ, Bando T, Kosaka S, Ariyasu T, Hitomi S (1996) ET-Kyoto solution for 48-hour canine lung preservation. Ann Thorac Surg 61: 963-968. doi: 10.1016/0003-4975(95)01118-8.
  • Watson AJ, Gao L, Sun L, Tsun J, Jabbour A, Ru Qiu M, Jansz PC, Hicks M, Macdonald PS (2013) Enhanced preservation of the rat heart after prolonged hypothermic ischemia with erythropoietin-supplemented Celsior solution. J Heart Lung Transplant 32: 633-640. doi: 10.1016/j.healun.2013.03.014.
  • Wei L, Hata K, Doorschodt BM, Büttner R, Minor T, Tolba RH (2007) Experimental small bowel preservation using Polysol: a new alternative to University of Wisconsin, Celsior and Histidine-Tryptophan-Ketoglutarate solution? World J Gastroenterol 13: 3684-3691.
  • Wittwer T, Wahlers T, Cornelius JF, Elki S, Haverich A (1999) Celsior solution for improvement of currently used clinical standards of lung preservation in an ex vivo rat model. Eur J Cardiothorac Surg 15: 667-671.
  • Yamamoto T, Mita A, Ricordi C, Messinger S, Miki A, Sakuma Y, Timoneri F, Barker S, Fornoni A, Molano RD, Inverardi L, Pileggi A, Ichii H (2010) Prolactin supplementation to culture medium improves beta-cell survival. Transplantation 89: 1328-1335. doi: 10.1097/TP.0b013e3181d98af1.
  • Yang J, Wang Y, Sui M, Liu F, Fu Z, Wang QX (2015) Tri-iodothyronine preconditioning protects against liver ischemia reperfusion injury through the regulation of autophagy by the MEK/ERK/mTORC1 axis. Biochem Biophys Res Commun 467: 704-710. doi: 10.1016/j.bbrc.2015.10.080.
  • Yoshida H, Okuno H, Kamoto T, Habuchi T, Toda Y, Hasegawa S, Nakamura T, Wada H, Ogawa O, Yamamoto S (2002) Comparison of the effectiveness of ET-Kyoto with Euro-Collins and University of Wisconsin solutions in cold renal storage. Transplantation 74: 1231-1236. doi: 10.1097/01.TP.0000034467.02725.24.
  • Zań R, Roliński Z, Kowalski C, Burmańczuk A, Polska B (2011) Biological properties and clinical use of melatonin in animals. Życie Weterynaryjne 86: 225-228
  • Zaouali MA, Ben Abdennebi H, Padrissa-Altés S, Alfany-Fernandez I, Rimola A, Roselló-Catafau J (2011) How Institut Georges Lopez preservation solution protects nonsteatotic and steatotic livers against ischemia-reperfusion injury. Transplant Proc 43: 77-79. doi: 10.1016/j.transproceed.2010.12.026.
  • Zaouali MA, Mosbah IB, Padrissa-Altés S, Calvo M, Abdennebi HB, Saidane-Mosbahi D, Bjaoui M, Garcia-Gil FA, Panisello A, Roselló-Catafau J (2010a) Relevance of epidermal growth factor to improve steatotic liver preservation in IGL-1 solution. Transplant Proc 42: 3070-3075. doi: 10.1016/j.transproceed.2010.07.071.
  • Zaouali MA, Padrissa-Altés S, Mosbah IB, Abdennebi HB, Boillot O, Rimola A, Saidane-Mosbahi D, Roselló-Catafau J (2010b) Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution. World J Gastroenterol 16: 5693-5700.
  • Zhao X, Koshiba T, Nakamura T, Tsuruyama T, Li Y, Bando T, Wada H, Tanaka K (2008) ET-Kyoto solution plus dibutyryl cyclic adenosine monophosphate is superior to University of Wisconsin solution in rat liver preservation. Cell Transplant 17: 99-109.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.