Ezetimibe prevents myocardial remodeling in an obese rat model by inhibiting inflammation

• Authors: Xiao-Xing Li , Lang Zhao , Ying Chang , Bao-Shan Liu , Feng Xu , Cheng Zhang , Xiao-Ping Ji , Yu-Guo Chen , Chuan-Bao Li
• Languages of publication: EN

Abstracts

EN

Inflammation plays an important role in the development of many obesity-related diseases. This study aimed to investigate the effect of ezetimibe on inflammation and myocardial remodeling in obese rats. A rat model of obesity was established, and myocardial damage was examined by transmission electron microscopy and Masson staining. Twenty obese rats were divided into two groups (n=10): obese group and ezetimibe group. Ten SD rats were used as controls. Western blot was performed to monitor the expression of P-p38MAPK and interleukin (IL)-6. Immunohistochemical staining was used to monitor the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. In the obese rats group, we observed increased inflammatory factors and myocardial hypertrophy. In contrast, the ezetimibe group exhibited decreased expression of inflammatory factors and an improvement in myocardial remodeling compared to the obese group. Mechanistically, we found that ezetimibe decreased P-p38MAPK, IL-6, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 levels in the hearts of the obese rats. Taken together, these results indicate that ezetimibe may improve myocardial remodeling in obese rats by inhibiting inflammation.

Keywords

EN

obese; inflammation; remodeling; ezetimibe; IL-6

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2018
• Volume: 65
• Issue: 3
• Pages: 465-470

Dates

published

2018

received

2018-04-01

revised

2018-05-28

accepted

2018-05-28

(unknown)

2018-09-08

Contributors

author

Xiao-Xing Li

• Department of Geriatrics, Qilu Hospital, Shandong University Jinan, Shandong, China
• Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China

author

Lang Zhao

• Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China

author

Ying Chang

• Department of Emergency, Chest Pain Center, Qilu Hospital, Shandong University, Jinan, Shandong, China
• Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China

author

Bao-Shan Liu

• Department of Emergency, Chest Pain Center, Qilu Hospital, Shandong University, Jinan, Shandong, China
• Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China

author

Feng Xu

• Department of Emergency, Chest Pain Center, Qilu Hospital, Shandong University, Jinan, Shandong, China
• Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China

author

Cheng Zhang

• Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China

author

Xiao-Ping Ji

• Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China

author

Yu-Guo Chen

• Department of Emergency, Chest Pain Center, Qilu Hospital, Shandong University, Jinan, Shandong, China
• Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China

author

Chuan-Bao Li

• Department of Emergency, Chest Pain Center, Qilu Hospital, Shandong University, Jinan, Shandong, China
• Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China

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Identifiers

DOI

10.18388/abp.2018_2597