NLCs as a potential carrier system for transdermal delivery of forskolin

• Authors: Elwira Lasoń , Elżbieta Sikora , Małgorzata Miastkowska , Elvira Escribano , Maria Garcia-Celma , Conxita Solans , Meritxell Llinas , Jan Ogonowski
• Languages of publication: EN

Abstracts

EN

Nanostructured lipid carriers (NLC) composed of the substances generally recognized as safe (GRAS) were obtained by using a hot high-pressure homogenization technique (HPH). The influence of the number of homogenization cycles and concentration of a decyl glucoside surfactant on the NLC properties were studied. The system's stability was assessed by macroscopic observation, light backscattering and zeta potential measurements. NLC particle size was measured using dynamic light scattering (DLS). The kinetically stable formulations were loaded with forskolin and selected for in vitro drug permeation study using the Franz cell method. Concentration of forskolin in the receptor solution (i.e. ethanol/PBS mixture) was analyzed with high performance liquid chromatography (HPLC) with UV detection. The obtained results have shown that NLC formulations could be used as effective carriers for forskolin permeation through the skin.

Keywords

EN

Forskolin; NLC; nanostructured lipid carrier; skin permeation

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2018
• Volume: 65
• Issue: 3
• Pages: 437-442

Dates

published

2018

received

2018-01-19

revised

2018-04-04

accepted

2018-07-26

(unknown)

2018-09-15

Contributors

author

Elwira Lasoń

• Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

author

Elżbieta Sikora

• Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

author

Małgorzata Miastkowska

• Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

author

Elvira Escribano

• Department of of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Joan XXIII s/n, E-08028 Barcelona, Spain. IN2UB members

author

Maria Garcia-Celma

• Department of of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Joan XXIII s/n, E-08028 Barcelona, Spain. IN2UB members

author

Conxita Solans

• Institute for Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC) Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) Barcelona, Spain

author

Meritxell Llinas

• Institute for Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC) Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) Barcelona, Spain

author

Jan Ogonowski

• Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland

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Identifiers

DOI

10.18388/abp.2018_2554