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2018 | 65 | 2 | 325-332
Article title

Differential effects of various soy isoflavone dietary supplements (nutraceuticals) on bacterial growth and human fibroblast viability

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EN
Abstracts
EN
Flavonoids, polyphenolic compounds present in many food products, affect growth of different bacterial species when tested as purified or synthetic substances. They can also influence gene expression in human cells, like fibroblasts. Here, we asked if soy isoflavone extracts, commonly used in many products sold as anti-menopausal dietary supplements, influence bacterial growth similarly to a synthetic isoflavone, genistein. Four commercially available products were tested in amounts corresponding to genistein concentrations causing inhibition of growth of Vibrio harveyi (a model bacterium sensitive to this isoflavone) and Escherichia coli (a model bacterium resistant to genistein). Differential effects of various extracts on V. harveyi and E. coli growth, from stimulation, to no changes, to inhibition, were observed. Moreover, contrary to genistein, the tested extracts caused a decrease (to different extent) in viability of human dermal fibroblasts. These results indicate that effects of various soy isoflavone extracts on bacterial growth and viability of human cells are different, despite similar declared composition of the commercially available products.
Publisher

Year
Volume
65
Issue
2
Pages
325-332
Physical description
Dates
published
2018
received
2018-03-30
revised
2018-04-16
accepted
2018-04-23
(unknown)
2018-05-22
Contributors
  • Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland
  • Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland
  • Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland
  • Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
  • Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland
  • Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland
  • Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv65p325kz
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