The interaction of new oxicam derivatives with lipid bilayers as measured by calorimetry and fluorescence spectroscopy

• Authors: Jadwiga Maniewska , Justyna Gąsiorowska , Berenika Szczęśniak-Sięga , Krystyna Michalak
• Languages of publication: EN

Abstracts

EN

The purpose of the present work was to assess the ability of five new oxicam analogues to interact with the lipid bilayers. To characterize the interaction of newly synthesized NSAIDs (non-steroidal anti-inflammatory drugs) analogues with DPPC lipid bilayers the two following techniques were applied - differential scanning calorimetry (DSC) and fluorescence spectroscopy. The results obtained by these experimental approaches show that new oxicams analogues interact with the lipid model membranes under consideration. As demonstrated both in calorimetric and spectroscopic studies, the greatest influence on the thermotropic properties of the lipid membrane and on the quenching of fluorescence of Laurdan and Prodan was exerted by a derivative named PR47 containing in its structure a two-carbon aliphatic linker with a carbonyl group, as well as bromine and trifluoromethyl substituents.

Keywords

EN

oxicam derivatives; NSAIDs analogues; piroxicam; 1,2- benzothiazine derivatives synthesis; model lipid bilayers; differential scanning calorimetry (DSC); fluorescence spectroscopy

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2018
• Volume: 65
• Issue: 2
• Pages: 185-191

Dates

published

2018

received

2018-02-02

revised

2018-04-13

accepted

2018-04-17

(unknown)

2018-05-22

Contributors

author

Jadwiga Maniewska

• Department of Chemistry of Drugs, Wroclaw Medical University, Wrocław, Poland

author

Justyna Gąsiorowska

• Department of Biophysics, Wroclaw Medical University, Wrocław, Poland

author

Berenika Szczęśniak-Sięga

• Department of Chemistry of Drugs, Wroclaw Medical University, Wrocław, Poland

author

Krystyna Michalak

• Department of Biophysics, Wroclaw Medical University, Wrocław, Poland

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Identifiers

DOI

10.18388/abp.2018_2604