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2018 | 65 | 2 | 185-191
Article title

The interaction of new oxicam derivatives with lipid bilayers as measured by calorimetry and fluorescence spectroscopy

Content
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EN
Abstracts
EN
The purpose of the present work was to assess the ability of five new oxicam analogues to interact with the lipid bilayers. To characterize the interaction of newly synthesized NSAIDs (non-steroidal anti-inflammatory drugs) analogues with DPPC lipid bilayers the two following techniques were applied - differential scanning calorimetry (DSC) and fluorescence spectroscopy. The results obtained by these experimental approaches show that new oxicams analogues interact with the lipid model membranes under consideration. As demonstrated both in calorimetric and spectroscopic studies, the greatest influence on the thermotropic properties of the lipid membrane and on the quenching of fluorescence of Laurdan and Prodan was exerted by a derivative named PR47 containing in its structure a two-carbon aliphatic linker with a carbonyl group, as well as bromine and trifluoromethyl substituents.
Publisher

Year
Volume
65
Issue
2
Pages
185-191
Physical description
Dates
published
2018
received
2018-02-02
revised
2018-04-13
accepted
2018-04-17
(unknown)
2018-05-22
Contributors
  • Department of Chemistry of Drugs, Wroclaw Medical University, Wrocław, Poland
  • Department of Biophysics, Wroclaw Medical University, Wrocław, Poland
  • Department of Chemistry of Drugs, Wroclaw Medical University, Wrocław, Poland
  • Department of Biophysics, Wroclaw Medical University, Wrocław, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv65p185kz
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