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2018 | 65 | 1 | 17-24
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The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases

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Autoimmune thyroid diseases include several distinct clinical entities, mainly Graves' disease and Hashimoto's thyroiditis. An incompetent immune response directed against the body's own tissues, and the production of antibodies against specific cell antigens accompanied by chronic inflammation, all occur in autoimmune thyroid diseases. The autoimmune process is induced by genetic and environmental factors that are difficult to identify and generates the development of concomitant diseases in other systems. Leukocyte activation and overproduction of inflammatory mediators, as well as improper levels of thyroid hormones, play an essential role in the chronic course of these diseases. The development of autoimmune thyroid diseases results from the impairment of the regulatory and suppressor functions of T-cells or NK cells and activation of B cells, or from the changes in the number of those cells. Many reports have shown the significant role of platelet-leukocyte interaction in inflammation. Autoantibodies react with target antigens in different kinds of cells, including blood platelets, and autoimmune processes can modulate the mutual cooperation of blood platelets and lymphocytes. The activity of blood platelets and lymphocytes is reciprocally regulated. It has been suggested that blood platelets can influence lymphocyte function by direct contact with receptors, and indirectly via soluble mediators. The interactions of platelet-immune cells (neutrophils, monocytes, lymphocyte and dendritic cells) can have a potent enhancing effect on immune cells functions.
Physical description
  • Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Łódź, Poland
  • Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Łódź, Poland
  • Akinci B, Comlekci A, Yener S, Demir T, Bayraktar F, Yuksel F, Yesil S (2007) The alteration of serum sCD40L levels in overt and subclinical hypothyroidism. Hormones (Athens) 6: 327-333. doi: 10.14310/horm.2002.1111029.
  • Alor P, Nash GB (1995) Adhesion of flowing leucocytes to immobilized platelets. Br J Haematol 89: 725-732.
  • Arao T, Morimoto I, Kakinuma A, Ishida O, Zeki K, Tanaka Y, Ishikawa N, Ito K, Ito K, Eto S (2000) Thyrocyte proliferation by cellular adhesion to infiltrating lymphocytes through the intercellular adhesion molekule-1/lymphocyte function-associated antygen-1 pathway in Graves' disease. J Clin Endocrinol Metab 85: 382-389. doi: 10.1210/jcem.85.1.6320.
  • Armengol MP, Cardoso-Schmidt CB, Fernandez M, Ferrer X, Pujol-Borrel R, Juan M (2003) Chemokines determine local lymphoneogenesis and a reduction of circulating CXCR4+ T and CCR7 B an T lymphocytes in thyroid autoimmune diseases. J Immunol 170: 6320-6328. doi: 10.4049/jimmunol.170.12.6320.
  • Armengol MP, Juan M, Lucas-Martin A, Fernandez-Figueras MT, Jaraquemada D, Gallart T, Pujol-Borrell R (2001) Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers. Am J Pathol 159: 861-873. doi: 10.1016/S0002-9440(10)61762-2.
  • Ayensu WK, Keku EO, Isokpehi RD, Farah IO, Arthur CA, Leggett SS (2011) Autoimmune Diseases: The Role of Environment and Gene Interactions. In Immunology, Allergology and Rheumatology Mavragani CP eds, pp 3-34. Intech. doi: 10.5772/19856
  • Balázs C (2012) The role of hereditary and environmental factors in autoimmune thyroid diseases. Orv Hetil 153: 1013-1022. doi: 10.1556/OH.2012.29370.
  • Ben-Skowronek I (2011) Hashimoto's thyroiditis - interactions of lymphocytes, thyroid cells and fibroblasts; graves' disease - the interaction of lymphocytes and thyroid cells. In Autoimmune Disorders-Pathogenetic, Mavragani CP eds, pp 231–254. Aspects. Croatia: InTech. doi: 10.5772/802
  • Ben-Skowronek I, Sierocinska-Sawa J, Korobowicz E, Szewczyk L (2008) Lymphocytes in peripheral blood and thyroid tissue in children with Graves' disease. World J Pediatr 4: 274-282. doi: 10.1007/s12519-008-0050-6.
  • Ben-Skowronek I, Szewczyk L, Sierocinska-Sawa J, Korobowicz E (2007) The subsets of lymphocytes in autoimmunological and non-autoimmunological thyroid diseases in children. Pediatr Endocrinol 6: 9-20
  • Bossowski A, Urban M, Stasiak-Barmuta A (2003) Analysis of circulating T gamma/delta lymphocytes and CD16/56 cell populations in children and adolescents with Graves' disease. Pediatr Res 54: 425-429. doi: 10.4322/acr.2015.002.
  • by Douglass A. Drelich and Paul F. Bray (2015) The Traditional Role of Platelets in Hemostasis. In The Non-Thrombotic Role of Platelets in Health and Disease, Kerrigan S, Moran N eds, pp 23-33, Intech. doi: 10.5772/60595
  • Chistiakov AD (2005) Immunogenetics of Hashimoto's thyroiditis. J Autoimmune Dis 2: 1-21. doi: 10.1186/1740-2557-2-1.
  • Cognasse F, Hamzeh-Cognasse H, Lafarge S, Chavarin P, Cogné M, Richard Y, Garraud O (2007) Human platelets can activate peripheral blood B cells and increase production of immunoglobulins. Exp Hematol 35: 1376-1387. doi: 10.1016/j.exphem.2007.05.021.
  • Cordiano I, Betterle C, Spadaccino CA, Soini B, Girolami A, Fabris F (1998) Autoimmune thrombocytopenia (AITP) and thyroid autoimmune disease (TAD): overlapping syndromes? Clin Exp Immunol 113: 373-378.
  • Dürk T, Duerschmied D, Müller T, Grimm M, Reuter S, Vieira RP, Ayata K, Cicko S, Sorichter S, Walther DJ, Virchow JC, Taube C, Idzko M (2013) Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation. Am J Respir Crit Care Med 187: 476-485. doi: 10.1164/rccm.201208-1440OC.
  • Esfahanian F, Naimi E, Doroodgar F, Jadali Z (2013) Th1/Th2 cytokines in patients with Graves' disease with or without ophthalmopathy. Iran J Allergy Asthma Immunol 12: 168-175.
  • Fröhlich E, Wahl R (2017) Thyroid autoimmunity: role of anti-thyroid antibodies in thyroid and extra-thyroidal diseases. Front Immunol 8: 521. doi: 10.3389/fimmu.2017.00521.
  • Ganesh BB, Bhattacharya P, Gopisetty A, Prabhakar BS (2011) Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity. J Interferon Cytokine Res 31: 721-731. doi: 10.1089/jir.2011.0049.
  • Gerenova J, Manolova I, Gadjeva V (2012) Hashimoto's disease - involvement of cytokine network and role of oxidative stress in the severity of hashimoto's thyroiditis. In A new look at hypothyroidism, pp 91-125. Drahomira Springer des, Croatia: InTech.
  • Hargett LA, Bauer NN (2013) On the origin of microparticles: From 'platelet dust' to mediators of intercellular communication. Pulm Circ 3: 329-340.
  • Hasegawa S, Pawankar R, Suzuki K, Nakahata T, Furukawa S, Okumura K, Ra C (1999) Functional expression of the high affinity receptor for IgE (FcεRI) in human platelets and its' intracellular expression in human megakaryocytes. Blood 93: 2543-2551.
  • Herter JM, Rossaint J, Zarbock A. (2014) Platelets in inflammation and immunity. J Thromb Haemost 12: 1764-1775. doi: 10.1111/jth.12730.
  • Iddah MA, Macharia BN (2013) Autoimmune thyroid disorders. ISRN Endocrinology 2013 509764. doi: 10.1007/s12026-014-8598-9.
  • Jiang H, Chess L (2006) Regulation of immune response by T- cells. N Engl J Med 354: 1166-1176. doi: 10.1056/NEJMra055446.
  • Kayahan H, Akarsu M, Ozcan MA, Demir S, Ates H, Unsal B, Akpinar H (2007) Reticulated platelet levels in patients with ulcerative colitis. Int J Colorectal Dis 22: 1429-1435. doi: 10.1007/s00384-007-0330-y.
  • Kimura H, Kimura M, Tzou SC, Chen YC, Suzuki K, Rose NR, Caturegli P (2004) Expression of class II major histocompatibility complex molecules on thyrocytes does not cause spontaneous thyroiditis, but mildly increases its severity after immunization. Endocrinology 146: 1154-1162. doi: 10.1210/en.2004-1165.
  • Kuznik BI, Vitkovsky YA, Gvozdeva OV, Solpov AV, Magen E (2014) Lymphocyte-Platelet Crosstalk in Graves' Disease. Am J Med Sci 347: 206-210. doi: 10.1097/MAJ.0b013e3182831726.
  • Li N (2008) Platelet-lymphocyte cross-talk. J Leukoc Biol 83: 1069-1078. doi: 10.1189/jlb.0907615.
  • Li N, Ji Q, Hjemdahl P (2006) Platelet-lymphocyte conjugation differs between lymphocyte subpopulations. J Thromb Haemost 4: 874-881. doi: 10.1111/j.1538-7836.2006.01817.x.
  • Liebman H (2007) Other immune thrombocytopenias. Semin Hematol 44: S24-S34. doi: 10.1053/j.seminhematol.2007.11.004.
  • Liu CY, Battaglia M, Lee SH, Sun QH, Aster RH, Visentin GP (2005) Platelet Factor 4 differentially modulates CD4+CD25+(Regulatory) versus CD4+CD25− (Non-regulatory) T cells. J Immunol 174: 2680-2686. doi: 10.4049/jimmunol.174.5.2680.
  • Marta GN, de Campos FP (2015) Immune thrombocytopenia and autoimmune thyroid disease: a controversial overlap. Autops Case Rep 5: 45-48.
  • McLachlan SM, Rapoport B (2013) Thyrotropin-blocking autoantibodies and thyroid-stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to hyperthyroidism or vice versa. Thyroid 23: 14-24. doi: 10.1089/thy.2012.0374.
  • McLachlan SM, Nagayama Y, Pichurin PN, Mizutori Y, Chen CR, Misharin A, Aliesky HA, Rapoport B (2007) The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells. Endocrinology 148: 5724-5733. doi: 10.1210/en.2007-1024.
  • Menconi F, Marcocci C, Marinò M (2014) Diagnosis and classification of Graves' disease. Autoimmun Rev 13: 398-402. doi: 10.1016/j.autrev.2014.01.013.
  • Popko K, Górska E (2015) The role of natural killer cells in pathogenesis of autoimmune diseases. Cent Eur J Immunol 40: 470-476. doi: 10.5114/ceji.2015.56971.
  • Pyzik A, Grywalska E, Matyjaszek-Matuszek B, Roliński J (2015) Immune disorders in Hashimoto's thyroiditis: what do we know so far? J Immunol Res 2015: 979167. doi: 10.1155/2015/979167.
  • Qin Q, Liu P, Liu L, Wang R, Yan N, Yang J, Wang X, Pandey M, Zhang JA (2012) The increased but non-predominant expression of Th17- and Th1-specific cytokines in Hashimoto's thyroiditis but not in Graves' disease. Braz J Med Biol Res. 45: 1202-1208.
  • Shenkman B, Brill G, Solpov A, Vitkovsky Y, Kuznik B, Koltakov A, Kotev-Emeth S, Savion N, Bank I (2006) CD4+ lymphocytes require platelets for adhesion to immobilized fibronectin in flow: role of beta (1) (CD29)-, beta(2) (CD18)-related integrins and non-integrin receptors. Cell Immunol 242: 52-59. doi: 10.1016/j.cellimm.2006.09.005.
  • Sit M, Aktas G, Kargi E, Savli H (2014) Mean platelet volume should be a useful indicator in diagnosis of Hashimoto's thyroiditis. Acta Medica Mediter 30: 1263-1266
  • Stokes KY, Granger DN (2012) Platelets: a critical link between inflammation and microvascular dysfunction. J Physiol 590: 1023-1034. doi: 10.1113/jphysiol.2011.225417.
  • Sugimoto K, Sasaki M, Isobe Y, Tamayose K, Hieda M, Oshimi K (2005) Improvement of idiopathic thrombocytopenic purpura by antithyroid therapy. Eur J Haematol 74: 73-74. doi: 10.1111/j.1600-0609.2004.00341.x.
  • Watanabe M, Nakamura Y, Matsuzuka F, Takamura Y, Miyauchi A, Iwatani Y (2008) Decrease of intrathyroidal CD161+Valpha24+Vbeta11+ NKT cells in Graves' disease. Endocr J 55: 199-203.
  • Weetman AP (2016) Autoimmune Thyroid Disease. In: Endocrinology: Adult and Pediatric, 2-Volume Set 7th Edition. Jameson JL, De Groot L, pp 1423-1436. Imprint.
  • Zantut-Wittmann DE, Tambascia MA, da Silva Trevisan MA, Pinto GA, Vassallo J (2001) Antithyroid drugs inhibit in vivo HLA-DR expression in thyroid follicular cells in Graves' disease. Thyroid 11: 575-580. doi: 10.1089/1050725017503028 86.
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